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(19)

(11)

2 756 584

(13)

(51)

IPC

C12N5/71(2010-01-01)

(21) (22)

Application

2016104823, 2010-10-28

(24)

Start date

2010-10-28

(22)

Actual filing date

2010-10-28

(45)

Published

2021-10-01

(72)

Inventor

Reid Lola M.Wang YunfangCardinale VincenzoGaudio EugenioCarpino GuidoAlvaro DomenicoCui Cai-Bin

(73)

Holder

The University Of North Carolina At Chapel HillSapienza Universita Di Roma

MULTIPOTENT STEM CELLS OF EXTRAHEPATIC BILE DUCTS AND METHODS FOR THEIR ISOLATION Russian patent published in 2021 - IPC C12N5/71

Abstract RU 2756584 C2

FIELD: cell biology; medicine.

SUBSTANCE: present invention relates to cell biology and medicine and discloses a composition for transplantation of a cell population to a patient and a method for the production of multipotent cells of a mammal. Cells, according to the invention, are capable of differentiating in several endodermal cell lines. They are obtained from the tissue of bile ducts, and they are positive by at least one surface marker of stem cells, namely EpCAM, N-CAM, CXCR4 or CD133, as well as by at least one marker of a pancreatic cell line, by at least one marker of a hepatic cell line and by at least one marker of an endodermal cell line.

EFFECT: present invention allows for creation of alternative and additional sources of transplanted functional stem cells and precursor cells for use in the clinic.

22 cl, 59 dwg, 7 ex

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RU 2 756 584 C2

Authors

Reid Lola M.

Wang Yunfang

Cardinale Vincenzo

Gaudio Eugenio

Carpino Guido

Alvaro Domenico

Cui Cai-Bin

Dates

2021-10-01—Published

2010-10-28—Filed