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(19)

(11)

2 348 620

(13)

(51)

IPC

C07D277/24(2006-01-01)

C07D277/56(2006-01-01)

C07D417/06(2006-01-01)

C07D417/12(2006-01-01)

A61K31/426(2006-01-01)

A61K31/496(2006-01-01)

A61K31/427(2006-01-01)

A61K31/4725(2006-01-01)

A61K31/5377(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2006113126/04, 2004-09-20

(24)

Start date

2004-09-20

(22)

Actual filing date

2004-09-20

(45)

Published

2009-03-10

(72)

Inventor

Lange Jozefus Kh.M.Kruse Kornelis G.Van Stejvenberg Kherman Kh.Slidregt Leonardus A.J.M.

(73)

Holder

Solvej Farmas'Jutikals B.V.

THIAZOL DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS Russian patent published in 2009 - IPC C07D277/24 C07D277/56 C07D417/06 C07D417/12 A61K31/426 A61K31/496 A61K31/427 A61K31/4725 A61K31/5377 A61P25/00

Abstract RU 2348620 C2

FIELD: chemistry.

SUBSTANCE: invention concerns new compounds of the formula (I) and pharmaceutically acceptable salts. Claimed compounds have modulation effect on CB cannabinoid receptor. In the general formula (I) , R and R₁ are the same or different and are phenyl optionally substituted by 1-3 substitutes Y, where Y is substitute selected out of group including chlorine, iodine, bromine, fluorine, on condition that X is not a sub-group (ii); or one of R and R₁ radicals is phenyl group, while the other radical is formed or linear C_2-8-alkyl group or benzyl group; X is one of the sub-groups (i) or (ii). Also invention concerns application of the compounds in obtaining pharmaceutical composition, pharmaceutical composition with modulation effect on CB cannabinoid receptor, and compound of the general formula (IV) with radical values as indicated in the claim.

EFFECT: enhanced efficiency of composition and treatment method.

5 cl, 1 tbl, 25 ex

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RU 2 348 620 C2

Authors

Lange Jozefus Kh.M.

Kruse Kornelis G.

Van Stejvenberg Kherman Kh.

Slidregt Leonardus A.J.M.

Dates

2009-03-10—Published

2004-09-20—Filed