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2 337 907

(13)

(51)

IPC

C07D233/64(2006-01-01)

C07D401/12(2006-01-01)

C07D403/12(2006-01-01)

A61K31/4164(2006-01-01)

A61P1/00(2006-01-01)

A61P3/04(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2006113197/04, 2004-10-19

(24)

Start date

2004-10-19

(22)

Actual filing date

2004-10-19

(45)

Published

2008-11-10

(72)

Inventor

Lange Jozefus Kh.M.Krjuse Kornilis G.Van Stejvenberg Kherman Kh.Kejzer Khiskias G.

(73)

Holder

Solvej Farmas'Jutikals B.V.

1-IMIDAZOLE DERIVATIVES AS MODULATORS OF CANNABINOID RECEPTORS Russian patent published in 2008 - IPC C07D233/64 C07D401/12 C07D403/12 A61K31/4164 A61P1/00 A61P3/04 A61P25/00

Abstract RU 2337907 C2

FIELD: chemistry.

SUBSTANCE: invention pertains to new compounds with general formula (I) , where: R and R_i stand for phenyl, which can be substituted with 1, 2, 3 or 4 substitutes, which can be identical or different and chosen from a group consisting of chlorine, iodine, bromine, fluorine, trifluoromethyl and cyano. R₂ and R₃ can be identical or different and represent C_1-5 branched or straight alkyl group. The alkyl group can be substituted with 1-3 fluorine atoms, or R₂ and R₃ - together with a nitrogen atom, with which they are bonded to, form pyrrolidine or piperidine ring. R₇ represents hydrogen, C_3-8 cycloalkyl, pyrrolidinyl or piperidinyl. The invention also pertains to salts of these derivatives used in pharmacology, as well as to compounds with general formula (IV), their pharmaceutical compositions, and their use.

EFFECT: obtaining new biologically active compounds which can function as modulators of cannabinoid receptors.

9 cl, 3 ex, 2 tbl

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RU 2 337 907 C2

Authors

Lange Jozefus Kh.M.

Krjuse Kornilis G.

Van Stejvenberg Kherman Kh.

Kejzer Khiskias G.

Dates

2008-11-10—Published

2004-10-19—Filed