BENZIMIDAZOLE AND IMIDAZO[4,5-c]PYRIDINE DERIVATIVES AS HEDGEHOG PATHWAY ANTAGONIST Russian patent published in 2014 - IPC C07D401/10 C07D401/14 C07D403/14 C07D413/14 A61K31/4184 A61K31/4188 A61P35/00 A61P19/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to organic chemistry, namely to a heterocyclic compound of formula I and its pharmaceutically acceptable salt, wherein if a chemical valency permits, i represents 1 or 2, R₁ represents H; a linear (C₁-C₄) alkyl group, R₂ represents H, Cl or F, X represents either N, or CR₃, R₃ represents H; halogen; a linear (C₁-C₄) alkyl or (C₁-C₄) alkoxyl group, Y represents Z represents O or NRx, Rx represents H or a linear or branched (C₁-C₄) alkyl, k is equal to 2, 3 or 4, n and p independently represents 2, and a sum of n+p cannot exceed 4, T represents H or a linear (C₁-C₄) alkyl group; T′ represents a linear C₁-C₃ alkyl chain substituted by either (C₁-C₆)-dialkylaminogroup, or a 5-6-merous saturated heterocycle containing one nitrogen atom and optionally containing the second heteroatom specified in O, such a heterocyclic ring is optionally substituted by a (C₁-C₄) alkyl chain at nitrogen atoms; or a 5-merous saturated heterocycle containing one nitrogen atom, such a heterocyclic ring is optionally substituted by a (C₁-C₄) alkyl chain at nitrogen atoms; r represents zero, 1; R′ represents di(C₁-C₄)alkylamino, (C₁-C₄)alkoxy; except for the compounds specified in the clause. The invention also refers to a pharmaceutical composition based on the compound of formula (I), using the compound of formula (I) and to a method of treating diseases, in which the hedgehog signalling pathway modulation is effective.

EFFECT: there are prepared new heterocyclic compounds possessing t effective biological properties.

20 cl, 193 ex