FIELD: medicine, pharmaceutics.
SUBSTANCE: invention concerns a composition for immunising a patient against a disease caused by Neisseria meningitidis. The composition under the invention contains conjugates of at least two of four serogroups of meningococcus A, C, W135 and Y, and at least two of specified conjugates contain the same carrier protein. Besides the composition contains a whole carrier in the unconjugated form in the concentration less than 10 mcg/ml. Additionally, the composition can contain one or more conjugated capsular saccharide and/or protein heteroantigens, e.g., diphtheria antigen, tetanus antigen, cellular or whole-cell pertussis antigen, hepatitis A or B virus antigen, etc. The invention presents sets for immunisation of patients against the disease caused by N. meningitidis, the method for preparing the composition and the method for appraising acceptability of the composition for immunisation.
EFFECT: invention minimises amount of unconjugated carrier protein in a vaccine and allows avoiding suppression as a problem of epitope suppression with a carrier gets a special importance if the set of conjugates with the same carrier protein is administered simultaneously.
30 cl, 1 tbl
