METHOD FOR PREDICTING AND DIAGNOSTIC EVALUATION OF DEGREE OF COMPENSATION OF CHRONIC LIVER IMPAIRMENT AND SEVERITY OF CLINICAL COURSE OF LIVER CIRRHOSIS Russian patent published in 2009 - IPC A61B10/00 G01N33/72 

FIELD: medicine.

SUBSTANCE: clinical and physiological examinations are done on a patient, as well as determination and quantitative grading of subsequent evaluation criteria, which include determination of somatic protein deficiency, determination of visceral protein deficiency from the level of serum albumin, determination of ascite intensity, determination of neurologic status, evaluation of central hemodynamics and determination of presence of jaundice from the level of bilirubin. Functional class is then determined from groups and transition groups A, A-B, B, B-C, C, to which the patient relates on presence of more than 3 parametres, corresponding to any given functional class, where group A is characterised by the following parametres: somatic protein deficiency 0-5%, visceral protein deficiency from the level of serum albumin >40, absence of ascite from USD data, neurologic status - absence of clinical and EEG encephalopathy features, central hemodynamic state - normal parametres, absence jaundice from the level of bilirubin, where functional class of this group characterises compensation stage of chronic hepatocellular impairment. Group A-B is characterised by the following parametres: somatic protein deficiency 5-10%, visceral protein deficiency from the level of serum albumin 40-35, absence of ascite from USD data, neurologic status - absence of clinical and EEG encephalopathy features, central hemodynamic state - normokinetic, increase in total peripheral resistance, presence of transient jaundice from the level of bilirubin, where functional class of this group characterises stage of relative compensation of chronic hepatocellular impairment. Group B is characterised by the following parametres: somatic protein deficiency 10-15%, visceral protein deficiency from the level of serum albumin 35-30, presence of ascite percussion in inclined places, neurologic status - presence of astenisation, central hemodynamic state - hyperkinetic, increase in circulating blood volume, more than 60 ml carbohydrates, presence of light jaundice from bilirubinemia, consisting of 1.5-2 doses, where functional class of this group characterises a stage of subcompensated chronic hepatocellular impairment. Group B-C is characterised by the following parametres: somatic protein deficiency 15-20%, visceral protein deficiency from the level of serum albumin 30-25, presence of moderate ascite - 1 stage of abdominal cavity, neurologic status - presence of latent encephalopathy, central hemodynamic state - normo-hypokinetic, positive sample volumes, 60-40 ml carbohydrates, mild jaundice from bilirubinemia, consisting of 3 doses, where functional class of this group characterises a stage of relative or early decompensation. Group C is characterised by the following parametres: somatic protein deficiency over 20%, visceral protein deficiency from the level of serum albumin less than 25, presence of intense ascite of 2 stages of abdominal cavity and more, neurologic status - acute encephalopathy of 1-2 degree, central hemodynamic state - reduction of all hemodynamic parametres, less than 40 ml carbohydrates, presence of severe jaundice from bilirubinemia consisting of more than 3 doses, where functional class of this group characterises stage of complete decompensation of chronic hepatocellular impairment.

EFFECT: increased accuracy of diagnosing liver diseases, accuracy of predicting course of a disease and extent of surgery.

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