ORGANIC COMPOUNDS Russian patent published in 2010 - IPC C07D471/04 A61K31/437 A61K31/4353 A61P37/00 

FIELD: chemistry.

SUBSTANCE: invention describes compounds of formula (I) in free or salt form, where Q is a bond, R¹ and R² independently represent H or C₁-C₈alkyl, or R³ is C₁-C₈alkyl, R⁴ and R⁵ independently represent halogen, C₁-C₈alkyl, C₁-C₈haloalkyl, C₃-C₁₅carbocyclic group, nitro group, cyano-group, C₁-C₈alkylsulphonyl group, R⁶ is H or C₁-C₈alkyl; W is a group of formula (W_a1) or (W_a2), where A independently represents C or N, or W represents a group of formula (W_b); where Y independently represents C or N; and Z represents N, O or S, or W represents a group of formula (W_c), where Y independently represents C or N; and Z represents O or S; X represents -SO₂-, -CH₂-, -CH(C₁-C₈alkyl)- or a bond; m and n each independently represents an integer from 0 to 3; and p is 1, to a pharmaceutical composition with CRTh2 antagonist activity, as well as to use thereof as a medicinal agent and production method thereof.

EFFECT: new compounds which can be used in medicine are obtained and described.

10 cl, 153 ex, 1 tbl