METHOD FOR PREPARING MODIFIED ASCORBIC ACID OF CROSS-LINKED HYALURONIC ACID SALT AND BASED BIOACTIVE COMPOSITION Russian patent published in 2010 - IPC C08B37/00 

FIELD: medicine.

SUBSTANCE: method for preparing implies a chemical interaction of hyaluronic acid salt, ascorbic acid and/or ascorbic acid salt together with a cross-linking agent. The initial reagents are simultaneously exposed to pressure within 5 to 1000 MPa and shear deformation in a mechanochemical reactor (Bridgman anvil or screw-type device) at temperature 20° to 50°C. The invention has allowed to create the universal ecologically safe method that ensures preparing the cross-linked hyaluronic acid salt with chemically modified ascorbic acid and/or its salts, in an one-step operating practice in absence of the fluid medium. The bioactive composition contains the modified hyaluronic acid salt and a functional additive, e.g. an antioxidant, food, stabilising, modifying, medicinal agent with molar relation of the components: the modified hyaluronic acid salt to the functional additive within 100:1 to 1:1.

EFFECT: invention allows expanding range of products, improving destruction stability of the composition with hydroxyl radical added and thereafter increasing considerably effectiveness of the composition.

25 cl, 17 ex