METHOD FOR SYNTHESIS OF CROSS-LINKED HYALURONIC ACID SALT MODIFIED WITH FOLIC ACID Russian patent published in 2010 - IPC C08B37/08 C08L5/00 A61K31/728 A23L1/03 

FIELD: chemistry.

SUBSTANCE: invention relates to methods for synthesis of cross-linked salts of hyaluronic acid (HA) which are modified with folic acid - a natural polymer from the polysaccharide family. The method involves chemical reaction of a salt of hyaluronic acid, folic acid together with at least one cross-linking agent, simultaneously subjecting the initial reagents to pressure ranging from 5 to 1000 MPa and shear deformation in a mechanochemical reactor at temperature ranging from 20°C to 50°C. The reactor used is preferably a Bridgman anvil or an auger-type device, e.g. a double-screw extruder.

EFFECT: design of a universal environmentally safe method which enables synthesis of a range of new, cross-linked salts of hyaluronic acid which are modified with folic acid, in a single-step production cycle in the absence of a liquid medium, to obtain desired products with quantitative output; the method does not require large energy-, labour- and water inputs, enables use of the most diverse salts of hyaluronic acid as initial reagents.

19 cl, 18 ex