FIELD: chemistry.
SUBSTANCE: salt of hyaluronic acid (HA) is reacted with tocopherol and at least one cross-linking agent, while subjecting initial reagents to simultaneous effect of pressure which ranges from 5 to 1000 MPa and shearing deformation in a mechanochemical reactor at temperature ranging from 20°C to 50°C, as well as to a bioactive composition based on said salt.
EFFECT: obtaining cross-linked salts of hyaluronic acid modified with tocopherol in single-step mode in the absence of a liquid medium, obtaining desired products with quantitative output.
25 cl, 18 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING MODIFIED ASCORBIC ACID OF CROSS-LINKED HYALURONIC ACID SALT AND BASED BIOACTIVE COMPOSITION | 2008 |
|
RU2382050C1 |
| METHOD FOR SYNTHESIS OF CROSS-LINKED SALT OF HYALURONIC ACID, MODIFIED WITH VITAMINES | 2008 |
|
RU2387671C1 |
| METHOD FOR SYNTHESIS OF CROSS-LINKED RETINOL-MODIFIED SALT OF HYALURONIC ACID | 2008 |
|
RU2386641C2 |
| METHOD FOR SYNTHESIS OF CROSS-LINKED RIBOFLAVIN-MODIFIED SALT OF HYALURONIC ACID | 2008 |
|
RU2386640C2 |
| METHOD FOR SYNTHESIS OF CROSS-LINKED HYALURONIC ACID SALT MODIFIED WITH FOLIC ACID | 2008 |
|
RU2387670C1 |
| SOLID-PHASE METHOD OF PRODUCING BIOACTIVE NANOCOMPOSITE | 2009 |
|
RU2416389C1 |
| METHOD FOR PREPARATION OF CURED HYALURONIC ACID SALTS | 2007 |
|
RU2366665C1 |
| METHOD FOR PREPARATION OF CURED HYALURONIC ACID SALTS IN WATER MEDIUM | 2007 |
|
RU2366666C1 |
| SOLID-PHASE METHOD FOR OBTAINING PHOSPHORYLATED HYALURONIC ACID FOR COSMETIC PURPOSES | 2021 |
|
RU2775654C1 |
| SOLID-PHASE METHOD OF PRODUCTION OF WATER-SOLUBLE BIOACTIVE NANOCOMPOSITE BASED ON HYALURONIC ACID MODIFIED BY CITRIC ACID AND GOLD NANOPARTICLES | 2013 |
|
RU2534789C1 |
