METHOD FOR SYNTHESIS OF CROSS-LINKED RIBOFLAVIN-MODIFIED SALT OF HYALURONIC ACID Russian patent published in 2010 - IPC C08B37/08 C08L5/00 A61K31/728 A23L1/03 

FIELD: chemistry.

SUBSTANCE: invention relates to synthetic polymer chemistry and more specifically to methods for synthesising cross-linked riboflavin-modified salts of hyaluronic acid (HA), which is a natural polymer from the polysaccharide class. The method involves chemical reaction of a salt of hyaluronic acid and riboflavin with at least one cross-linking agent, while subjecting the initial reagents to simultaneous reaction at pressure ranging from 5 to 1000 MPa and shear deformation in a mechanochemical reactor at temperature ranging from 20°C to 50°C. The reactor used is preferably a Bridgman anvil or an auger-type device, e.g. a double-screw extruder. The method does not require large energy, labour and water inputs, enables use of a wide variety of initial reagents, including water-insoluble salts of hyaluronic acid.

EFFECT: design of a universal environmentally safe method which enables production of a range of cross-linked riboflavin-modified salts of hyaluronic acid in a single-step process without a liquid medium, obtaining desired products with quantitative output.

17 cl, 17 ex