Show metadata Hide metadata

(19)

(11)

2 382 783

(13)

(51)

IPC

C07D417/12(2006-01-01)

A61K31/427(2006-01-01)

A61P11/06(2006-01-01)

(21) (22)

Application

2006109545/04, 2004-08-27

(24)

Start date

2004-08-27

(22)

Actual filing date

2004-08-27

(45)

Published

2010-02-27

(72)

Inventor

Blumfild Grehm CharlzBrus AjanKhajler Dzhudi FoksLeblan KatrinLe-Grand Darren MarkMakkarti Klajv

(73)

Holder

Novartis Ag

ORGANIC COMPOUNDS Russian patent published in 2010 - IPC C07D417/12 A61K31/427 A61P11/06

Abstract RU 2382783 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound which is 1-[2-(2-ethyl-2H-tetrazol-5-yl)ethyl]-3-[5-(3-fluoro-4-methanesulfonylphenyl)-4-methylthiazol-2-yl]urea in free form or in form of a pharmaceutically acceptable salt.

EFFECT: composition has inhibitory activity on phosphatidylinositol-3-kinase, which contains the disclosed compound as an active ingredient, to use of the compound to prepare a pharmaceutical composition for treating diseases mediated by phosphatidylinositol-3-kinase and synthesis method thereof.

6 cl, 9 tbl, 154 ex

Similar patents RU2382783C2

Title	Year	Author	Number
SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE	2014	Xi Ning Wang Liang Wang Tingjin	RU2683793C2
PYRIMIDOPYRIDAZINE DERIVATIVES APPLICABLE AS P38 MAP KINASE	2010	Besvik Amanda Vashkovych Bogdan	RU2516466C2
HYDANTOIN DERIVATIVES USED AS MMP INHIBITORS	2007	Chapman Dehvid Gabos Balint Munk Av Rozenshold Magnus	RU2463301C2
COMBINATIONS CONTAINING ANTIMUSCARINE AGENTS AND CORTICOSTEROIDS	2005	Gras Ehskardo Khordi Rajder Khamish Orvis Dias Pio Llenas Kal'Vo Khesus	RU2385721C2
HYDROBROMIDE SALT OF N-(4-CHLORO-2-HYDROXY-3-((3S)-3-PIPERIDINYLSULFONYL)PHENYL)-N'-(3-FLUORO-2-METHYLPHENYL)UREA	2014	Sanderson Frensis Dominik Vollens Sara Meri	RU2685408C1
CHEMICAL COMPOUNDS I	2005	Taker Khauard	RU2381216C2
XINAFOATE SALT OF N4-[(2,2-DIFLUORO-4H-BENZO[1,4]OXAZIN-3-ON)-6-YL]-5-FLUORO-N2-[3-(METHYLAMINOCARBONYL METHYLENEOXY)PHENYL]-2,4-PYRIMIDINE DIAMINE	2008	Tehjlor Stefan Kolin Dzhon	RU2458925C2
MORPHOLINO-SUBSTITUTED DERIVATIVES OF UREA OR CARBAMATE AS MTOR INHIBITORS	2012	Lynch Rosemary Cansfield Andrew David Hardy Daniel Paul Sunose Mihiro Morel Adeline Convery Laura Adrego Rita	RU2616619C2
UREA DERIVATIVES AND THERAPEUTIC USE THEREOF IN TREATING, AMONG OTHER THINGS, RESPIRATORY TRACT DISEASES	2011	Voo Chi-Kit Van Nil Monik Bodil	RU2586223C2
COMBINATIONS CONTAINING ANTIMUSCARINIC AGENTS AND INHIBITORS PDE4	2005	Gras Ehskardo Khordi Llenas Kal'Vo Khesus Rajder Khamish Orvis Dias Pio	RU2404772C2

RU 2 382 783 C2

Authors

Blumfild Grehm Charlz

Brus Ajan

Khajler Dzhudi Foks

Leblan Katrin

Le-Grand Darren Mark

Makkarti Klajv

Dates

2010-02-27—Published

2004-08-27—Filed