HEXAFLUOROISOPROPANOL-SUBSTITUTED ETHER DERIVATIVES Russian patent published in 2010 - IPC C07C43/23 C07C59/68 C07C65/24 C07C69/734 C07C69/92 C07D249/06 C07D261/08 C07D261/20 C07D263/32 C07D275/04 A61K31/85 A61K31/192 A61K31/216 A61K31/235 A61K31/42 A61K31/423 A61K31/428 A61K31/4192 A61P1/00 A61P3/00 A61P17/00 A61P25/00 

Abstract RU 2383524 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel hexafluoroisopropanol-substituted ether derivatives of formula (I) to their pharmaceutically acceptable salts and to esters which are capable of bonding with LXR-alpha and/or LXR-beta, as well as to pharmaceutical compositions based on said compounds. In formula (I) R1 is hydrogen, lower alkyl or halogen, one of groups R2 and R3 is hydrogen, lower alkyl or halogen, and the second of groups R2 and R3 is -O-CHR4-(CH2)m-(CHR5)n-R6. Values of R4, R5, R6 m and n are given in the formula of invention.

EFFECT: novel compounds have useful biological properties.

22 cl, 4 dwg, 102 ex

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Authors

Demlou Genrietta

Kun Bernd

Pandaj Narenda

Ratni Khasane

Rajt Matt'Ju Blejk

Dates

2010-03-10Published

2005-09-22Filed