FIELD: chemistry.
SUBSTANCE: invention relates to oligonucleotide probes and their compositions which can be used to analyse the representative sample of a genome. An algorithm is proposed, which employs genome transformation and an auxiliary data structure for fast and accurate calculation of the quantity of a specific nucleotide motive in a genome. Such an algorithm can be used to identify oligonucleotide probes according to this invention. Provided also are systems and methods of analysing differences in the number of copies nucleotide sequences and comparing the level of methylation between two genomes.
EFFECT: invention proposes a simple genome analysis method owing to virtual presentation with minimum risk of cross hybridisation and possibility of avoiding oversized or undersized presentation of certain sequences during genome analysis.
71 cl, 12 dwg, 2 tbl, 12 ex
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