FIELD: chemistry; biochemistry.
SUBSTANCE: invention relates to biotechnology, specifically to obtaining hybrid proteins, and can be used in medicine during therapy of tuberculosis of the lungs, severe pneumonia, thermochemical inhalation burns, silicosis, respiratory distress syndrome and other diseases of the lungs. The hybrid protein gamma-interferon-surfactant-C which is expressed in Escherichia coli is obtained using a recombinant technique.
EFFECT: invention enables address delivery of gamma-interferon into lungs.
3 cl, 6 dwg, 1 tbl
Title |
Year |
Author |
Number |
METHOD FOR OBTAINING A HYBRID PROTEIN CONTAINING A FUSED PROTEIN ANALOGUE OF AN INTERFERON GAMMA CONJUGATED WITH OLIGOSACCHARIDE |
2016 |
- Martynov Aleksandr Igorevich
- Sankov Mikhail Nikolaevich
- Gasanov Vagif Ali Ogly
- Shevale Aleksandr Fedorovich
- Vlasov Aleksandr Alekseevich
- Shilovskij Igor Petrovich
|
RU2656140C2 |
RECOMBINANT PLASMID pET32a-IFG144 PROVIDING SYNTHESIS OF INTERFERON GAMMA, BACTERIAL STRAIN ESCHERICHIA COLI JM109/pET32a-IFG144 PRODUCER OF INTERFERON GAMMA PROTEIN AND METHOD FOR OBTAINING INTERFERON GAMMA |
2022 |
- Chumburidze Georgij Georgievich
|
RU2787131C1 |
DNA S54 FRAGMENT ENCODING POLYPEPTIDE SHOWING ACTIVITY OF GAMMA-INTERFERON, RECOMBINANT PLASMID DNA PROVIDING THE SYNTHESIS OF POLYPEPTIDE WITH ACTIVITY OF GAMMA-INTERFERON, AND THE STRAIN OF ESCHERICHIA COLI - A PRODUCER OF POLYPEPTIDE WITH GAMMA-INTERFERON ACTIVITY |
1992 |
- Tat'Kov S.I.
- Smirnova O.Ju.
- Kishchenko G.P.
- Petrenko V.A.
|
RU2046144C1 |
FUSION PROTEIN, ESCHERICHIA COLI STRAIN BEING FUSION PROTEIN PRODUCER AND METHOD FOR PRODUCING METHIONINE-FREE HUMAN INTERFERON ALPHA-2b OF SUCH FUSION PROTEIN |
2010 |
- Kozlov Dmitrij Georgievich
- Cheperegin Sergej Ehduardovich
- Gubajdullin Irek Il'Jasovich
- Jakovenko Andrej Romanovich
- Kazarov Aleksandr Aleksandrovich
|
RU2441072C1 |
METHOD OF PREPARING POLYPEPTIDE SHOWING PROPERTY OF HUMAN GAMMA-INTERFERON |
1988 |
- Dehvid V.Goeddel[Us]
- Patrik V.Grej[Us]
|
RU2092561C1 |
RECOMBINANT PLASMID DNA pGD-14 CONTAINING HYBRID GENE, INCLUDING NUCLEOTIDE SEQUENCE OF DEXTRAN-BINDING DOMAIN OF BETACOCCI, JOINED WITH HUMAN INTERFERON-GAMMA GENE THROUGH ACID-LABILE SPACER, DETERMINING BIOSYNTHESIS OF CHIMERIC PROTEIN STRUCTURE |
2011 |
- Grishin Dmitrij Viktorovich
- Sdobnova Marina Jur'Evna
|
RU2470072C1 |
RECOMBINANT PLAZMIDNAJA DNA pTrcIFdL CODING POLYPEPTIDE WITH HUMAN GAMMA INTERFERON ACTIVITY AND Escherichia coli BACTERIA STRAIN - PRODUCER OF POLYPEPTIDE WITH HUMAN GAMMA INTERFERON ACTIVITY |
2009 |
- Shingarova Ljudmila Nikolaevna
- Boldyreva Elena Filippovna
- Tikhonov Roman Vladimirovich
- Jakimov Sergej Aleksandrovich
- Vul'Fson Andrej Nikolaevich
- Dolgikh Dmitrij Aleksandrovich
- Kirpichnikov Mikhail Petrovich
|
RU2399670C1 |
STRAIN OF BACTERIA Escherichia coli JM109/pHINS21 - PRODUCER OF HYBRID PROTEIN WITH HUMAN PROINSULIN AND METHOD FOR PRODUCTION OF HUMAN PROINSULIN |
2007 |
- Rodionov Petr Ivanovich
- Rodionov Petr Petrovich
- Shmatchenko Vadim Vasil'Evich
- Stepanov Aleksej Vjacheslavovich
- Bajdus' Aleksandr Nikolaevich
- Shmatchenko Natal'Ja Anatol'Evna
- Gorkun Taras Alekseevich
|
RU2376368C2 |
RECOMBINANT PLASMIDS pET32a-IFG144, PROVIDING INTERFERON GAMMA SYNTHESIS, BACTERIAL STRAIN ESCHERICHIA COLI JM109/pET32a-IFG144 - INTERFERON GAMMA PROTEIN PRODUCER, METHOD OF OBTAINING INTERFERON GAMMA AND MEDICINAL PRODUCT |
2022 |
- Chumburidze Georgij Georgievich
|
RU2809358C1 |
HYBRID PROTEIN (VERSIONS), BACTERIAL STRAIN ESCHERICHIA COLI - HYBRID PROTEIN PRODUCER (VERSIONS) AND METHOD FOR PRODUCING METHIONINE-FREE HUMAN INTERFERON ALPHA-2 |
2011 |
- Kozlov Dmitrij Georgievich
- Jakovenko Andrej Romanovich
- Tezov Vladimir Adol'Fovich
|
RU2453604C1 |