METHOD OF PREPARING CHIRAL AMLODIPINE GENTISATE Russian patent published in 2010 - IPC C07D211/90 C07D213/80 C07D213/83 

FIELD: chemistry.

SUBSTANCE: present invention relates to a method of preparing optically pure amlodipine gentisate involving the following steps: a) preparation of diastereomeric mixture of amlodipine dibenzoyltartrate from racemic (R,S)-amlodipine using isopropanol solvent and optically pure O,O'-dibenzoyltartaric acid with subsequent optical isolation; and b) treatment of the isolated amlodipine dibenzoyltartrate diastereomer with a base and then obtaining optically pure amlodipine gentisate by adding gentisic acid to the resulting free form in a single continuous step.

EFFECT: continuous method is described for preparing optically pure amlodipine gentisate with good yield and high optical purity.

11 cl, 2 ex