METHOD FOR PRODUCTION OF AMLODIPINE ENANTIOMER OF HIGH OPTIC PURITY Russian patent published in 2009 - IPC C07D211/90 C07D213/803 

FIELD: medicine.

SUBSTANCE: method for production of optically pure solvate dimethyl formamide of L-hemiartrate(S)-amlodipine includes stages of processing of (R,S)-amlodipine base with L-tartaric acid in presence of dimethyl formamide and cosolvent. Invention is also related to solvate DMFA of L-hemiartrate(S)-amlodipine, solvate of DMFA of L-hemiartrate(R)-amlodipine, solvate of dimethyl formamide L-hemiartrate(S)-amplodipine, produced according to clause 1 and characterised with the following spectrum ¹H NMR: ¹H NMR (CDCl₃): 8.01 (s, 1H, CHO); 7.04-7.41 (m, 4H); 5.40 (s, 1H); 4.72 (kk, 2H), 4.36 (s, 1H), 4.02 (m, 2H), 3.77 (m, 2H), 3.57 (s, 3H), 3.28 (m, 2H), 3.0 (s, 3H; DMFA); 2.8 (s, 3H; DMFA); 2.31 (s, 3H), 1.15 (t, 3H), and also to methods for production of salt of hemipentahydrate bezylate(S)-amlopidine, salt of dihydrate of bezylate(S)-amlodipine.

EFFECT: production of specified compound by economic and industrially realisable method with high enantiomer purity.

20 cl, 14 ex, 1 dwg