FIELD: chemistry.
SUBSTANCE: invention relates to a method of obtaining optically active amlodipine trough optical separation of (R,S)-amlodipines where (R,S)-amlodipine reacts with optically active O,O'-dibenzoyl- tartaric acid in an isopropanol solvent to obtain optically active salt of amlodipine-hemi-dibenzoyl-L-tartrate or its solvate, and the optically active salt of amlodipine-hemi-dibenzoyl-L-tartrate or its solvate is treated with a base to obtain optically active amlodipine. The invention also relates to (R)-(+)-amlodipine-hemi-dibenzoyl-L-tartrate, (S)-(-)-amlodipine-hemi-dibenzoyl-D-tartrate, (S)-(-)-amlodipine-hemi-dibenzoyl-L-tatrate, (R)-(+)- amlodipine-hemi-dibenzoyl-D-tatrate or solvates thereof.
EFFECT: obtaining enantiomerically pure amlodipine isomers with activity calcium channel blocker properties.
23 cl, 18 ex, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PREPARING CHIRAL AMLODIPINE GENTISATE | 2006 |
|
RU2393150C2 |
| METHOD OF ISOLATING R-(+)- AND S-(-)-AMPLODIPIN ISOMERS FROM MIXTURES THEREOF, (R)-(+) AND S-(-)-AMPLODIPIN-HEMI- L- OR D-TARTRATE SOLVATES AND MONOHYDRATES | 1995 |
|
RU2132845C1 |
| METHOD FOR PRODUCTION OF AMLODIPINE ENANTIOMER OF HIGH OPTIC PURITY | 2005 |
|
RU2376288C2 |
| (S)-(-)-AMLODIPINE CAMSYLATE OR ITS HYDRATE AND PHARMACEUTICAL COMPOSITION INCLUDING THEM | 2007 |
|
RU2403241C1 |
| TRANSISOMERIC HETEROCYCLIC COMPOUNDS AND THEIR PRODUCTION | 2018 |
|
RU2759443C2 |
| AMLODIPINE GENTISATE AND ITS OBTAINING METHOD | 2004 |
|
RU2330843C2 |
| METHOD OF SYNTHESIS OF PURE ENANTIOMERS OF 1,4-DIHYDROPYRIDINES, PURE ENANTIOMERS OF 1,4-DIHYDROPYRIDINES AND ISOTHIOUREIDES | 1990 |
|
RU2069658C1 |
| METHOD OF PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NAPHYRIDINE-3-CARBOXAMIDE BY SEPARATION OF THE RACEMATE USING A DIASTEREOMERIC COMPOSITE TARTARIC ACID ESTER | 2019 |
|
RU2805573C2 |
| AMLODIPINE OPTICAL ISOMER SEPARATION METHOD | 2008 |
|
RU2357781C1 |
| CHIRAL SEPARATION OF MIXTURE OF NICOTINE ENANTIOMERS | 2018 |
|
RU2753492C1 |
