KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS Russian patent published in 2010 - IPC C07H17/08 C07H1/00 A61K31/7048 A61P31/04 

FIELD: chemistry.

SUBSTANCE: present invention relates to antibacterial compounds of general formula I ,

where R¹ is hydrogen; R² is alkyl; R³ is alkyl, alkenyl, cycloalkyl or COR¹¹, where R¹¹ is alkyl, provided that R² and R³ do not simultaneously denote methyl; W denotes alkenyl; -G(CH₂)_qJ-, where q varies from 2 to 6; G is absent; J is absent or denotes -N(R¹²)(CH₂)_m, where m = 0; R¹² is alkyl; R is a heterocycle; R⁴ is ethyl; R' is methyl; Y is fluorine; and Z is oxygen. The invention also relates to a range of specific compounds listed in the formula of invention. The invention also relates to several different methods for synthesis of compounds of general formula XIII

, where R³ is alkyl, alkenyl, cycloalkyl, or COR¹¹, where R¹¹ is C₁ - C₆ alkyl, provided that R³ is not methyl; W is G(CH₂)_qJ-, where q varies from 2 to 6; G is absent, J is absent or denotes N(R¹²)(CH₂)_m, where m = 0; R¹² is alkyl; and R is a heterocycle.

EFFECT: obtaining novel antibacterial compounds.

7 cl, 6 ex