METHOD OF DETERMINING BORDERS OF SKIN AND MUCOUS MEMBRANE NEOPLASMS Russian patent published in 2010 - IPC A61N5/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine and is intended for determining borders of skin and mucous membrane neoplasms. Irradiation of neoplasm and surrounding it area, which obviously belongs to unchanged tissues, with light is performed. Digital image of non-induced autofluorescence in range of wavelength larger with respect to light irradiation is obtained. On said image arrays of n_norm points and n_tum points are singled out and brightness of each point of areas is determined. Frequency of occurrence of points with different brightness is calculated, frequency of occurrence is registered in one-dimensional arrays and synthetic array is formed by given formula. After that mean value of function of synthetic distribution is determined by formula. Array of n-points, located in window with symmetry centre in point with coordinates (x, y) is singled out, brightness for each point of array is determined and frequency of occurrence of points with different brightness is calculated. Frequency of occurrence is registered in two-dimensional array and mean occurrence is determined. Probability of passing of boundary tumour-unchanged tissue in point with coordinates (x, y) is determined by given formula and by local maximums, formed by points with adjacent coordinates, neoplasm boundaries are determined.

EFFECT: method allows to increase accuracy of determining boundaries of skin and mucous membrane neoplasms by analysis of fluorescent images of neoplasm zone, obtained without application of preparations which induce autofluorescence.

1 ex, 4 dwg