DIFFERENTIAL DIAGNOSTIC TECHNIQUE FOR BENIGN AND MALIGNANT NONPIGMENTED SKIN GROWTH Russian patent published in 2014 - IPC A61B5/00 G01N33/533 

FIELD: medicine.

SUBSTANCE: invention refers to medicine. According to the method, 3 hours after oral administration of the preparation Alasens 15 mg/kg of the body weight, a three-channel RGB fluorescence imaging of a zone of interest is formed. A part of the red channel in the tumour imaging is estimated. The value R_cut=(R/(R+G+B))·100% is calculated, wherein R_cut is the part of the red channel in the tumour imaging, R, G and B are the brightness values of the red, green and blue channels of the intact skin. The formed three-channel RGB fluorescence imaging is used to create a grey shade imaging l(x,y). The relation $$I1(x,y)=\frac{R(x,y)}{R(x,y)+G(x,y)+B(x,y)}\cdot 100\%$$ is calculated for each imaging point I(x,y), wherein R(x,y), G(x,y), B(x,y) are the brightness values of the red, green and blue channels RGB of the fluorescent imaging with the coordinates x, y. The operation I(x,y)=0 is carried out for the points wherein the value $$\left[\frac{I1(x,y)-R_{cut}}{R_{cut}}\cdot 100\%\right]$$ is less than 10%. If the tumour is displayed in the derived result imaging l(x,y), it is diagnosed as malignant, while the benign tumour tends to disappear from the imaging.

EFFECT: method enables providing higher information value ensured by more accurate imaging of the malignant tumour borders.

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