METHOD OF SELECTIVE DESTRUCTION OF MALIGNANT CELLS BY MAGNETIC MICROCONTAINERS WITH PHOTODYNAMIC OR PHOTOTHERMAL DYES Russian patent published in 2010 - IPC A61N5/67 A61B18/04 A61N2/08 B82B1/00 A61K33/26 A61K9/51 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention concerns medicine, oncology, and can be used for selective destruction of tumours. For this purpose, a photosensitiser is encapsulated in polymeric microcontainers enclosed in shells that contain magnetite (Fe₃O₄) nanoparticles, and introduced in the surrounding biological tissue. The external constant magnetic field with its spatial configuration matched with the tumour shape is generated in the tumour bulk. Laser exposure follows within a given period corresponding to maximum accumulation of the microcontainers in the tumour at radiant energy density sufficient for photodynamic or photothermal destruction of the microcontainers shells in the tumour and following photodynamic or photothermal destruction of malignant cells. The photosensitiser is specified with an absorption band chosen with an absorption strip in red and close IR-spectral region 650-1200 nm.

EFFECT: method allows more effective destruction of cancer cells ensured by higher degree of photosensitiser accumulation in the tumour with minimal destruction of the surrounding healthy cells and a surgical procedure without general anaesthesia.

4 cl, 9 dwg