THERMAL SENSITISER FOR LASER HYPERTHERMIA AND METHOD FOR PRODUCING IT Russian patent published in 2013 - IPC A61N5/67 B82B1/00 A61K31/13 A61K31/375 A61K31/74 A61K33/38 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention refers to nanotechnology of new materials applicable in biology, veterinary science and medicine, particularly for laser hyperthermia of new growths. What is presented is a method differing from known ones by agent concentrations, pH values of a reaction mixture, and particle surface functionalisation. At the first stage, gold spherical particles of the diameter of 1-3 nm used as a templates for the further growth of non-spherical particles are synthetised. At the second stage, gold is additionally reduced by ascorbic acid on the particles in cetyl trimethyl ammonium bromide in an acid medium (pH=1). At the third stage, cetyl trimethyl ammonium bromide molecules on the particle surface are substituted by polyethylene glycol for reducing biotoxicity of gold nanorods. The method uses the ingredients taken in specific molar ratios. What is also presented is a thermal sensitiser which is produced by the method above and representing a gold nanorod suspension. The rods are 30-45 nm long, 9-12 nm wide and coated by polyethylene glycol molecules.

EFFECT: invention provides higher stability and reproducibility of the gold nanorod synthesis with biotissue infrared absorption, as well as reduced toxicity of the thermal sensitiser.

2 cl, 6 dwg