METHOD FOR SELECTIVE DESTRUCTION OF MELANOMA Russian patent published in 2009 - IPC A61K31/195 A61P35/00 A61N5/67 B82B1/00 

FIELD: medicine; oncology.

SUBSTANCE: method includes introduction of solution of chemical compound of amino acid L-phenylalanine with gold or silver nanoparticles intravenously prior to radiation. At that minimum concentration of nanoparticles is 10⁸ cm^-3, and maximum concentration is 10¹² cm^-3. Plasma resonance of nanoparticles has spectral maximum in the area of biotissues transparency at the wave length of 750-1200 nm. These nanoparticles are gold or silver nanoshells with core of silicon dioxide or nanorods. Radiation of melanoma is performed at least after 1 hour and not more than after 4 hours after solution introduction, laser beam with length of radiation wave that coincides with spectral maximum of nanoparticles plasma resonance absorption. At that radiation is done by sequence of laser impulses with duration of laser impulse in the range of 10 microseconds - 100 ns at minimum porosity of three and higher, at energy density of at least 20 J/cm², but not more than 200 J/cm².

EFFECT: local performance of melanoma destruction with minimum destruction of surrounding healthy cells.

10 dwg