METHOD OF SELECTIVE LASER PHOTOTHERMOLYSIS OF CANCER CELLS BY PLASMON RESONANCE NANOPARTICLES Russian patent published in 2018 - IPC A61N5/67 B82B1/00 A61K9/51 A61K33/38 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to oncology, and can be used for selective laser photothermolysis of cancer cells by plasmon resonance nanoparticles. Colloidal solution of gold nanoparticles is introduced in the blood. Superficially located tumor is irradiated with resonant pulse laser radiation with a wavelength value in the region of the spectral maximum of nanoparticle absorption. Gold nanoparticles are conjugated to monoclonal antibodies for selective interaction with appropriate molecular probes on a membrane of cancer cells. Laser irradiation is performed with the help of a spatial discrete layer-by-layer 3D scan with the help of an acute-focused laser beam with a minimum focal spot size, defined by the average transverse size of cancer cells. Spatial scanning of the laser beam is carried out at a speed, at which, for each discrete scan step equal to the focal spot size, there is at least one laser pulse with energy in the range of 1-100 μJ. Duration of each pulse is 1-100 ns. Pulse relative duration is not less than 1000 with an average laser power not exceeding 1 W.

EFFECT: method provides selective photothermolysis of cancer cells located in the tissue volume, with minimal damage to normal cells.

1 cl, 8 dwg