FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to a method for making a new compound 4-benzoyl-1H-benzo[c] oxepin-3-one of formula: 
consisting in the fact that 2-benzoyl-3-(2-bromomethylphenyl)propenic ethyl ether prepared by bromination of 2-benzoyl-3-(2-methylphenyl)propenic ethyl ethyl ether with N-bromsuccinimide, heated at temperature 230-260°C with simultaneous ethyl bromide distillation for 15-45 minutes. 4-Benzoyl-1H-benzo[c]oxepin-3-one shows analgesic activity.
EFFECT: preparation of the new compound showing analgesic activity.
1 cl, 1 tbl, 2 ex
| Title |
Year |
Author |
Number |
| METHOD FOR SYNTHESIS OF ALKYL ESTERS OF 3-OXO-1,3-DIHYDROBENZO[C]OXEPIN-4-CARBOXYLIC ACID |
2008 |
- Glukhov Andrej Andreevich
- Kirillov Nikolaj Fedorovich
|
RU2387648C1 |
| DERIVATIVES OF HETEROCYCLIC BENZOCYCLOALKENES AND METHOD OF THEIR SYNTHESIS |
1998 |
- Tsimmer Osval'D
- Shtrassburger Vol'Fgang
- Pjutts Klaudia
- Ehngl'Berger Verner
- Kegel' Babette-Ivonne
|
RU2197484C2 |
| METHOD OF PRODUCING 2-(1,2,3-THIADIAZOL-4-YL)BENZYLAMINE HYDROCHLORIDE |
2023 |
- Pevzner Leonid Markovich
- Petrov Mikhail Lvovich
|
RU2825395C1 |
| USE OF 5-BENZOYL-4-HYDROXY-N-(4-IODOPHENYL)-6-(4-CHLOROPHENYL)-2-OXOHEXAHYDROPYRIMIDINE-4-CARBOXAMIDE AS AGENT WITH ANALGESIC ACTIVITY |
2023 |
- Gorgopina Ekaterina Vladimirovna
- Zamaraeva Tatiana Mikhailovna
- Rudakova Irina Pavlovna
- Gein Vladimir Leonidovich
|
RU2811249C1 |
| METHOD FOR PRODUCING METHYL 1-[(1,3-DIOXO-2,3-DIHYDRO-1H-INDEN-2-YL)-(4-METHYLPHENYL)METHYL]CYCLOHEXANE CARBOXYLATE SHOWING ANALGESIC ACTIVITY |
2013 |
- Kirillov Nikolaj Fedorovich
- Nikiforova Elena Aleksandrovna
- Makhmudov Ramiz Ragibovich
- Mardanova Ljudmila Gennad'Evna
|
RU2549566C2 |
| N-R-AMIDES OF (Z)-2[(3-ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO [b]THIEN-2-YL)AMINO]-4-PHENYL-4-OXOBUT-2-ENOIC ACIDS, HAVING ANALGESIC ACTIVITY |
2012 |
- Shipilovskikh Sergej Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Rubtsov Aleksandr Evgen'Evich
|
RU2501795C1 |
| 2-[(2-METHYLPHENYL)IMINO]-9-OXO-7-PHENYL-8-(3-PHENYL-2-QUINOXALINYL)-1,6-DIOXASPIRO[4,4]-NONE-3,7-DIENE-3,4-DICARBOXYLIC ACID DIMETHYL ESTER SHOWING ANTINOCICEPTIVE ACTIVITY AND METHOD FOR PRODUCING IT |
2013 |
- Lisovenko Natal'Ja Jur'Evna
- Makhmudov Ramiz Ragibovich
- Drjakhlov Artem Vasil'Evich
|
RU2556995C2 |
| ETHYL 4-(5-BENZOYL-6-(4-(DIETHYLAMINO)PHENYL)-4-HYDROXY-2-THIOXOHEXAHYDROPYRIMIDIN-4-CARBOXAMINO)BENZOATE, EXHIBITING ANALGESIC AND ANTI-INFLAMMATORY ACTION |
2019 |
- Gejn Vladimir Leonidovich
- Gorgopina Ekaterina Vladimirovna
- Zamaraeva Tatyana Mikhajlovna
- Rudakova Irina Pavlovna
- Dozmorova Natalya Viktorovna
|
RU2717246C1 |
| 6,6-DIMETHYL-8-OXO-5,6,8,9-TETRAHYDROBENZO[F]-PYRROLO[2,1-ALPHA]ISOQUINOLINE-9-SPIRO-2-(3-AROYL-4-HYDROXY-1-O-HYDROXYPHENYL-5-OXO-2,5-DIHYDRO-1H-PYRROLES) AND 6,6-DIMETHYL-8-OXO-5,6,8,9-TETRAHYDROBENZO[F]PYRROLO[2,1-ALPHA]ISOQUINOLINE-9-SPIRO-2-(3-BENZOYL-4-HYDROXY-1-O-HYDROXYPHENYL-5-OXO-2,5-DIHYDRIO-1H-PYRROLE) ELICITING ANALGESIC ACTIVITY AND METHOD FOR THEIR PREPARING |
2006 |
- Anikina Lada Vladimirovna
- Racheva Nadezhda L'Vovna
- Maslivets Andrej Nikolaevich
- Shkljaev Jurij Vladimirovich
|
RU2316557C1 |
| ETHYL 1,6-DIARYL-4-AROYL-3-HYDROXY-2-OXO-8-PHENYL-1,7-DIAZASPIRO[4,4]NONA-3,6,8-TRIEN-9-CARBOXILATES AND METHOD OF THEIR OBTAINING |
2011 |
- Silajchev Pavel Sergeevich
- Makhmudov Ramiz Ragibovich
- Maslivets Andrej Nikolaevich
|
RU2467010C1 |
