FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 2-(1,2,3-thiadiazol-4-yl)benzylamine hydrochloride. Disclosed method is based on reaction of 1-[2-(1,2,3-thiadiazol-4-yl)benzyl]-1,3,5,7-tetraazaadamantanilium bromide with hydrogen chloride in molar ratio of 1:5 in ethanol at 75°C for 1 hour, filtering the reaction mass to separate ammonium salts, evaporating the filtrate to dryness, suspending the residue in a mixture of ethyl acetate and hexane in a volume ratio of 1:2, filtering and drying. Invention also relates to a method of producing bromide 1-[2-(1,2,3-thiadiazol-4-yl)benzyl]-1,3,5,7-tetraazaadamantanilium 4-(2-bromomethylphenyl)-1,2,3-thiadiazole with 1,3,5,7-tetraazaadamantane and a method of producing 4-(2-bromomethylphenyl)-1,2,3-thiadiazole.
EFFECT: disclosed method for synthesis of 2-(1,2,3-thiadiazol-4-yl)benzylamine hydrochloride is cheaper and is characterized by less waste solvents and waste water.
3 cl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | 2009 |
|
RU2503660C2 |
| PATHOGENIC BACTERIA-INHIBITING BIOLOGICALLY ACTIVE SUBSTANCES AND METHOD OF INHIBITING PATHOGENIC BACTERIA TYPE III SECRETION | 2010 |
|
RU2447066C2 |
| SUBSTITUTED DERIVATIVES OF 4-AMINOCYCLOHEXANE | 2009 |
|
RU2525236C2 |
| SUBSTITUTED DERIVATIVES OF 4-AMINOCYCLOHEXANE | 2009 |
|
RU2532545C2 |
| 2H- OR 3H-BENZO[E]INDAZOL-1-YL-CARBAMATE DERIVATIVES AND USE THEREOF IN THERAPY | 2005 |
|
RU2379293C2 |
| MACROLIDES AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2000 |
|
RU2243230C2 |
| CHEMICAL COMPOSITIONS, FORMULATIONS AND METHODS OF THEIR APPLICATION | 2005 |
|
RU2413720C2 |
| METHOD FOR PRODUCING 1-HEXENE FROM ETHYLENE BY TRIMERISATION | 2015 |
|
RU2581052C1 |
| NEW 1-(-D-RIBOFURANOSIL-3-(5-SUBSTITUTED-1,2,4-OXADIAZOLE-3-YL)-1,2,4-TRIAZOLES WITH ANTI-VIRAL PROPERTIES AND METHOD FOR THEIR PRODUCTION | 2016 |
|
RU2629360C1 |
| METHOD OF PRODUCING 2-PHENYL-3-ALKYLQUINOLINES | 2014 |
|
RU2565787C1 |
