METHOD OF TREATING ONCOLOGICAL DISEASES Russian patent published in 2021 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and concerns a method for selection of supporting immunotherapy after the end of the primary complex treatment of a malignant growth of the breast, sigmoid colon and melanoma. Substance of the method consists in the fact that in peripheral blood of the patient the amount TNF-α, INF-γ, IL-2; CD4⁺, CD8⁺, CD19⁺, total number of lymphocytes and neutrophils. Further, formula Cr=nCD3⁺_stim / nCD3⁺_spont, where Cr is a reaction coefficient of influencing the course of the tumor process for the respective pro-inflammatory cytokine, namely: TNF-α, INF-γ, IL-2; nCD3⁺_stim – number of T-lymphocyte (CD3⁺) cells synthesizing the corresponding cytokine in the standard test system after stimulation; CD3⁺_spont – number of CD3+ T-lymphocyte cells synthesizing the corresponding cytokine spontaneously. That is followed by calculating the ratio of absolute values of neutrophils to total lymphocytes (NEU / LYMF), ratio of absolute values of neutrophils to lymphocyte subpopulations CD4⁺(NEU/CD4⁺), ratio of absolute values of neutrophils to lymphocyte subpopulations CD8⁺(NEU/CD8⁺), ratio of absolute values of neutrophils to lymphocyte subpopulations CD19⁺(NEU/CD19⁺). Depending on the obtained data, a supporting immunotherapy is prescribed.

EFFECT: use of the method enables higher effectiveness of primary complex treatment of malignant growths.

1 cl, 1 tbl, 4 ex