3-CYCLYL-2-(4-SULPHAMOYLPHENYL)-N-CYCLYLPROPIONAMIDE DERIVATIVES APPLICABLE FOR TREATING IMPAIRED GLUCOSE TOLERANCE AND DIABETES Russian patent published in 2011 - IPC C07D211/62 C07D513/04 C07D241/20 C07D213/75 C07D239/42 C07D241/04 C07D277/46 C07D277/82 A61K31/427 A61K31/4439 A61K31/454 A61K31/495 A61P3/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of formula in which Q together with carbon and nitrogen atoms whereto attached forms a 9-10-member bicyclic heterocycle, and R₁ and R₂, R₃, R₄, R₅ and R₆ are as specified in cl.1 of the patent claim, or to its enantiomers, or a mixture of its enantiomers, or to its pharmaceutically acceptable salt. Also, an invention refers to a method for activation of glucokinase activity in mammals, by introduction of the compound described above, to a method of treating the pathological conditions associated with glucokinase activity and impaired glucose tolerance by means of introduction of the compound of formula I, to a pharmaceutical composition on the basis of the presented compounds, and also to application of the compounds of formula I for preparing the pharmaceutical composition.

EFFECT: there are produced and described new compounds which are activators of glucokinase activity and can be used as therapeutic agents for preventing and treating impaired glucose tolerance, insulin-independent diabetes and obesity.

14 cl, 4 ex