FIELD: medicine.
SUBSTANCE: invention refers to a method of producing succinic acid with using a Yarrowia lipolytica yeast strain, Russian National Collection of Industrial Microorganisms No. Y-3314. Said yeast is modified in such a manner that they have lowered succinate dehydrogenase activity. The method involves a stage of yeast strain incubation in a nutrient medium containing glycerine, and recovery of succinic acid from a culture fluid.
EFFECT: use of the Yarrowia lipolytica strain, Russian National Collection of Industrial Microorganisms No Y-3314 has ensured substantially increased yield of succinic acid in this method.
2 cl, 2 dwg, 5 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MUTANT OF RUMEN BACTERIAUM OF Mannheimia TYPE (VERSIONS)-PRODUCER OF SUCCINIC ACID, METHOD OF ITS PRODUCTION (VERSIONS), METHOD FOR PRODUCTION OF SUCCINIC ACID | 2004 |
|
RU2376369C2 |
| NEW CONSTRUCTED MICROORGANISM PRODUCING HOMOSUCCINIC ACID, AND METHOD FOR PRODUCING SUCCINIC ACID WITH APPLYING THEREOF | 2007 |
|
RU2415942C2 |
| INTEGRATIVE pQ-SRUS GENETIC STRUCTURE FOR OBTAINING Yarrowia lipolytica YEAST STRAINS HAVING ABILITY FOR HOMOLOGICAL RECOMBINATION OF GENOME OF MITOCHONDRIA DUE TO EXPRESSION OF RecA PROTEIN GENE OF BACTERIAL ORIGIN | 2014 |
|
RU2562869C1 |
| STRAIN OF YEAST Yarrowia lipolytica VKPM Y-3753 - PRODUCENT OF SUCCINIC ACID | 2012 |
|
RU2487931C1 |
| RECOMBINANT BACTERIAL STRAIN Escherichia coli THAT IS SUCCINIC ACID PRODUCER (VERSIONS) AND METHOD FOR PREPARING SUCCINIC ACID WITH USING THIS STRAIN | 2012 |
|
RU2528056C2 |
| METHOD OF OBTAINING 2,4-DIHYDROXYBUTYRIC ACID | 2011 |
|
RU2626531C2 |
| STRAIN OF BACTERIA ESCHERICHIA COLI-SUCCINIC ACID PRODUCER (VERSIONS) AND METHOD FOR PREPARING SUCCINIC ACID USING THIS STRAIN | 2015 |
|
RU2603004C1 |
| STRAIN OF BACTERIA ESCHERICHIA COLI - PRODUCER OF FUMARIC ACID AND METHOD OF OBTAINING FUMARIC ACID USING THIS STRAIN | 2014 |
|
RU2573936C1 |
| GENETIC STRUCTURE FOR EXPOSING PROTEIN ON Yarrowia lipolytica YEAST CELL WALL SURFACE | 2010 |
|
RU2451749C1 |
| BACTERIUM Escherichia coli - SUCCINIC ACID PRODUCER AND METHOD FOR PREPARING SUCCINIC ACID | 2010 |
|
RU2466186C2 |
