FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to new compounds of the class spiro[chromen-4,3'-pyrrols], namely to ethyl 1'-R1-3-R2-2-amino-7,7-dimethyl-2', 5-dioxo-5'-phenyl-1',2',5',6,7,8-hexahydrospiro [chromen-4,3'-pyrrol]-4'-carboxylates of formula 
, where R1=CH2Ph, Ph, C6H11-c, H; R2=CN, COOMe, and to a method for producing them by reaction of 1'-R1-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrol-3-carboxylates with malononitrile or methyl cyanoacetate and dimedone in a aprotonic solvent medium.
EFFECT: production of new compounds which can be used as initial products for synthesis of new heterocyclic systems and in pharmacology as those exhibiting analgesic activity.
5 cl, 1 tbl
| Title |
Year |
Author |
Number |
| ETHYL 5-ALKYL-7,7-DIMETHYL-2',9,11-TRIOXO-5'-PHENYL-1',2',5,6,7,8,9,11-OCTAHYDROSPIRO{INDENO[1,2-b][QUIOLINE-10,3'-PYRROL}-4'-CARBOXYLATES AND METHOD FOR PREPARING THEM |
2012 |
- Dmitriev Maksim Viktorovich
- Silajchev Pavel Sergeevich
- Makhmudov Ramiz Ragibovich
- Maslivets Andrej Nikolaevich
|
RU2485120C1 |
| ETHYL 3',7-DIOXO-5'-PHENYL-1,6-DIHYDRO-1'H-SPIRO{INDENO[1,2-b]QUINOLINE-6,3'-PYRROLE}-4'-CARBOXYLATES AND SYNTHESIS METHOD THEREOF |
2010 |
- Dmitriev Maksim Viktorovich
- Makhmudov Ramiz Ragibovich
- Silajchev Pavel Sergeevich
- Maslivets Andrej Nikolaevich
|
RU2453549C1 |
| (Z)-1'-R-6',6'-DIMETHYL-3-(PHENYL(ARYLAMINO)METHYLENE)-6',7'-DIHYDRO-3H-SPIRO[FURANE-2,3'-INDOL]-2',4,4',5(1'H,5'H)TETRAONS AND METHOD OF THEIR OBTAINING |
2008 |
- Maslivets Andrej Nikolaevich
- Silajchev Pavel Sergeevich
- Aliev Zajnutdin Gasanovich
|
RU2365592C1 |
| METHYL 1-ARYL-3-HYDROXY-3'-METHYL-2,4,5'-TRIOXO-6-PHENYL-2,4,5,6-TETRAHYDRO-5'H-SPIRO[INDOLE-7,4'-ISOXAZOLE]-7a(1H)-CARBOXYLATES, METHYL 1-ARYL-(1'-PHENYL AND 1'-BENZYL)-3-HYDROXY-3'-METHYL-2,4,5'-TRIOXO-6-PHENYL-1',2,4,5,5',6-HEXAHYDROSPIRO[INDOLE-7,4'-PYRAZOLE]-7a(1H)-CARBOXYLATES AND METHYL 1'-ARYL-3'-HYDROXY-1,2',3,4'-TETRAOXO-6'-PHENYL-1,2',3,4',5',6'-HEXAHYDROSPIRO[INDENE-2,7'-INDOLE]-7a'(1'H)-CARBOXYLATES, DEMONSTRATING ANALGESIC ACTIVITY AND METHOD FOR OBTAINING THEREOF |
2014 |
- Silajchev Pavel Sergeevich
- Filimonov Valerij Olegovich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2577528C2 |
| METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-1,6-DIPHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-6-STYRYL-1-PHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHOD FOR PREPARING THEM |
2012 |
- Maslivets Andrej Nikolaevich
- Bubnov Nikolaj Vladimirovich
- Silajchev Pavel Sergeevich
- Filimonov Valerij Olegovich
- Makhmudov Ramiz Ragibovich
|
RU2495039C1 |
| METHOD OF PRODUCING ETHYL 2-AMINO-2',5-DIOXO-5'-PHENYL-3-CYANO-1',2'-DIHYDRO-5H-SPIRO{INDENO[1,2-B]PYRAN-4,3'-PYRROLE}-4'-CARBOXYLATES |
2014 |
- Maslivets Andrej Nikolaevich
- Dmitriev Maksim Viktorovich
- Silajchev Pavel Sergeevich
- Makhmudov Ramiz Ragibovich
|
RU2569898C1 |
| 2'-AMINO-2,5'-DIOXO-5-PHENYL-1,2,5',6',7',8'-HEXAHYDRO-1'H-SPIRO[PYRROL-3,4'-QUINOLINES] |
2020 |
- Maslivets Andrej Nikolaevich
- Dmitriev Maksim Viktorovich
- Balandina Svetlana Yurevna
- Sabitov Andrej Aleksandrovich
- Salnikova Tatyana Vladislavovna
|
RU2743922C1 |
| ETHYL 1'-BENZYL-3,3-DIMETNYL-1,2'-DIOXO-5'-PHENYL-1'2,2',3,4,10-HEXAHYDRO-1H-SPIRO[ACRIDINE-9,3'-PYRROL]-4'-CARBOXYLATES AND SYNTHESIS METHOD THEREOF |
2008 |
- Maslivets Andrej Nikolaevich
- Silajchev Pavel Sergeevich
- Makhmudov Ramiz Ragipovich
- Dmitriev Maksim Viktorovich
- Fedorovtseva Anastasija Nikolaevna
|
RU2387651C1 |
| METHYL 5-(ARYLCARBAMOYL) -1-(BENZYL AND PHENYL)-4-CINNAMOYL-1H-PYRAZOLE-3-CARBOXYLATES, EXHIBITING ANALGESIC ACTIVITY AND SYNTHESIS METHOD THEREOF |
2014 |
- Silajchev Pavel Sergeevich
- Filimonov Valerij Olegovich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2583158C2 |
| 1,6'-DIARYL-3-AROYL-4-HYDROXY-1',3'-DIMETHYLSPIRO[PIRROLE-2,5'-PYRROLO[2,3-d]PYRIMIDINE]-2',4',5(1H,1'H,3'H)-TRIONES AND METHOD FOR PRODUCTION THEREOF |
2012 |
- Silajchev Pavel Sergeevich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
|
RU2502738C2 |
