Show metadata Hide metadata

(19)

(11)

2 577 528

(13)

(51)

IPC

C07D487/10(2006-01-01)

C07D498/10(2006-01-01)

C07D209/96(2006-01-01)

A61K31/4162(2006-01-01)

A61K31/424(2006-01-01)

A61K31/404(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2014123248/04, 2014-06-06

(24)

Start date

2014-06-06

(22)

Actual filing date

2014-06-06

(45)

Published

2016-03-20

(72)

Inventor

Silajchev Pavel SergeevichFilimonov Valerij OlegovichMaslivets Andrej NikolaevichMakhmudov Ramiz Ragibovich

(73)

Holder

Federalnoe Gosudarstvennoe Bjudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Professionalnogo Obrazovanija Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"Obshchestvo S Ogranichennoj Otvetstvennostju

METHYL 1-ARYL-3-HYDROXY-3'-METHYL-2,4,5'-TRIOXO-6-PHENYL-2,4,5,6-TETRAHYDRO-5'H-SPIRO[INDOLE-7,4'-ISOXAZOLE]-7a(1H)-CARBOXYLATES, METHYL 1-ARYL-(1'-PHENYL AND 1'-BENZYL)-3-HYDROXY-3'-METHYL-2,4,5'-TRIOXO-6-PHENYL-1',2,4,5,5',6-HEXAHYDROSPIRO[INDOLE-7,4'-PYRAZOLE]-7a(1H)-CARBOXYLATES AND METHYL 1'-ARYL-3'-HYDROXY-1,2',3,4'-TETRAOXO-6'-PHENYL-1,2',3,4',5',6'-HEXAHYDROSPIRO[INDENE-2,7'-INDOLE]-7a'(1'H)-CARBOXYLATES, DEMONSTRATING ANALGESIC ACTIVITY AND METHOD FOR OBTAINING THEREOF Russian patent published in 2016 - IPC C07D487/10 C07D498/10 C07D209/96 A61K31/4162 A61K31/424 A61K31/404 A61P29/00

Abstract RU 2577528 C2

FIELD: chemistry.

SUBSTANCE: invention relates to derivatives of spiro[indole-7,4'-isoxazoles] of formula V

wherein Ar = Ph (a), C₆H₄Me-4 (b), C₆H₄Me-4 (c) and spiro[indole-7,4'-pyrazoles] of formula VI wherein Ar = Ph, R = Ph (a), CH₂Ph (b), Ar = C₆H₄Me-4, R = Ph (c), CH₂Ph (d), Ar = C₆H₄Me-4, R = Ph (e), CH₂Ph (f). The invention also relates to method for obtaining formulae V and VI compounds.

EFFECT: increased analgesic activity.

5 cl, 1 tbl, 4 ex

Similar patents RU2577528C2

Title	Year	Author	Number
1,1'-DIARYL-3'-AROYL-4'-HYDROXY-1H-SPIRO [INDENO[1,2-b]PYRROL-3,2'-PYRROL]-2,4,5'-(1'H)-TRIONES AND METHOD OF THEIR OBTAINING	2011	Bubnov Nikolaj Vladimirovich Denislamova Ekaterina Sergeevna Makhmudov Ramiz Ragibovich Maslivets Andrej Nikolaevich	RU2467011C1
7-AMINO-2,2',4-TRIOXO-5'-PHENYL-1,1',2,2',3,4-HEXAHYDROSPIRO{PYRANO[2,3-d]PYRIMIDIN-5,3'-PYRROL}-6-CARBONITRILES AND SYNTHESIS METHOD THEREOF	2015	Dmitriev Maksim Viktorovich Maslivets Andrej Nikolaevich Meljukhin Pavel Vasilevich Balandina Svetlana Jurevna	RU2604878C1
METHYL 5-(ARYLCARBAMOYL) -1-(BENZYL AND PHENYL)-4-CINNAMOYL-1H-PYRAZOLE-3-CARBOXYLATES, EXHIBITING ANALGESIC ACTIVITY AND SYNTHESIS METHOD THEREOF	2014	Silajchev Pavel Sergeevich Filimonov Valerij Olegovich Maslivets Andrej Nikolaevich Makhmudov Ramiz Ragibovich	RU2583158C2
ETHYL-2-AMINO-7,7-DIMETHYL-2',5-DIOXO-5'-PHENYL-1',2',5,6,7,8-HEXAHYDROSPIRO[CHROMEN-4,3'-PYRROL]-4'-CARBOXYLATES AND METHOD FOR PRODUCING THEM	2010	Dmitriev Maksim Viktorovich Silajchev Pavel Sergeevich Maslivets Andrej Nikolaevich Makhmudov Ramiz Ragipovich	RU2435774C1
(Z)-1'-R-6',6'-DIMETHYL-3-(PHENYL(ARYLAMINO)METHYLENE)-6',7'-DIHYDRO-3H-SPIRO[FURANE-2,3'-INDOL]-2',4,4',5(1'H,5'H)TETRAONS AND METHOD OF THEIR OBTAINING	2008	Maslivets Andrej Nikolaevich Silajchev Pavel Sergeevich Aliev Zajnutdin Gasanovich	RU2365592C1
1'-ARYL-1-BENZYL-4'-HYDROXY-6,6-DIMETHYL-3'-CINNAMOYL-6,7-DIHYDROSPIRO[INDOLE-3,2'-PYRROLE]-2,4,5'(1H,1'H,5H)-TRIONES AND 1,1'-DIARYL-4'-HYDROXY-6,6-DIMETHYL-3'-CINNAMOYL-6,7-DIHYDROSPIRO[INDOLE-3,2'-PYRROLE]-2,4,5'(1H,1',5H)-TRIONES, EXHIBITING ANALGESIC ACTIVITY, AND METHOD FOR PRODUCTION THEREOF	2012	Silajchev Pavel Sergeevich Maslivets Andrej Nikolaevich Filimonov Valerij Olegovich Makhmudov Ramiz Ragibovich	RU2520005C2
METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-1,6-DIPHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-6-STYRYL-1-PHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHOD FOR PREPARING THEM	2012	Maslivets Andrej Nikolaevich Bubnov Nikolaj Vladimirovich Silajchev Pavel Sergeevich Filimonov Valerij Olegovich Makhmudov Ramiz Ragibovich	RU2495039C1
INTERMEDIATE PRODUCTS - METHYL 7-ARYL-4, 9-DIAROYL-3-HYDROXY-1-(2-HYDROXYPHENYL)-2,6-DIOXO-1, 7-DIAZASPIRO[4,4]NONE-3, 8-DIENE-8-CARBOXYLATES; METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4,10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO[6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATES; METHOD OF PRODUCING METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4, 10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO [6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATES; METHYL 11-BENZOYL-2-O-HYDROXYPHEHYL-3, 4, 10-TRIOXO-9-P-TOLYL-6-PHENYL-7-OXA-2, 9-DIAZATRICYCLO [6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATE HAVING ANTIMICROBIAL ACTIVITY	2008	Racheva Nadezhda L'Vovna Maslivets Andrej Nikolaevich Aleksandrova Galina Arsent'Evna	RU2383550C1
1'-ARYL-4'-HYDROXY-3'-CYNNAMOYL-2H,4H-SPIRO[FURO[3,2-c]CHROMEN-3,2'-PYRROL]-2,4,5'(1'H)-TRIONES EXHIBITING ANALGESIC ACTIVITY, AND METHOD FOR PRODUCING THEM	2014	Silajchev Pavel Sergeevich Filimonov Valerij Olegovich Maslivets Andrej Nikolaevich Makhmudov Ramiz Ragibovich	RU2577523C2
ETHYL 5-ALKYL-7,7-DIMETHYL-2',9,11-TRIOXO-5'-PHENYL-1',2',5,6,7,8,9,11-OCTAHYDROSPIRO{INDENO[1,2-b][QUIOLINE-10,3'-PYRROL}-4'-CARBOXYLATES AND METHOD FOR PREPARING THEM	2012	Dmitriev Maksim Viktorovich Silajchev Pavel Sergeevich Makhmudov Ramiz Ragibovich Maslivets Andrej Nikolaevich	RU2485120C1

RU 2 577 528 C2

Authors

Silajchev Pavel Sergeevich

Filimonov Valerij Olegovich

Maslivets Andrej Nikolaevich

Makhmudov Ramiz Ragibovich

Dates

2016-03-20—Published

2014-06-06—Filed