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2 435 779

(13)

(51)

IPC

C07J63/00(2006-01-01)

(21) (22)

Application

2010117485/04, 2010-04-30

(24)

Start date

2010-04-30

(22)

Actual filing date

2010-04-30

(45)

Published

2011-12-10

(72)

Inventor

Popov Sergej AleksandrovichKozlova Ljubov' PavlovnaKornaukhova Ljubov' MikhajlovnaTolstikov Genrikh Aleksandrovich

(73)

Holder

Novosibirskij Institut Organicheskoj Khimii Im. N.N. Vorozhtsova Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran) Gosudarstvennogo Uchrezhdenija)

METHOD OF PRODUCING BETULIN 28-HEMISUCCINATE Russian patent published in 2011 - IPC C07J63/00

Abstract RU 2435779 C1

FIELD: chemistry.

SUBSTANCE: invention relates to an improved method of producing betulin 28-hemisuccinate from mother solutions from crystallising betulin from birch bark extracts. Method involves hydrolysis of mother solutions in an alkaline alcohol solution, concentrating and washing the organic extract with calcium chloride solution, treating the obtained mixture with succinic anhydride with selective acylation of betulin on the primary alcohol group in the presence of organic bases (pyridine, triethylamine) while heating to not more than 40°C. Purification is carried out by washing off impurity compounds with an organic solvent.

EFFECT: efficient method.

1 cl, 3 ex, 1 tbl

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RU 2 435 779 C1

Authors

Popov Sergej Aleksandrovich

Kozlova Ljubov' Pavlovna

Kornaukhova Ljubov' Mikhajlovna

Tolstikov Genrikh Aleksandrovich

Dates

2011-12-10—Published

2010-04-30—Filed