SELF-PRESERVED WATER PHARMACEUTICAL COMPOSITIONS Russian patent published in 2011 - IPC A61K9/08 A61K47/02 A61K47/10 A61K47/26 A61P27/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to medicine, in particular to ophthalmology. Self-preserved compositions are preserved effectively by means of a balanced buffer system containing zinc ions in the concentration 0.04-0.9 mm, preferentially 0.04-0.4 mm. One aspect of the balanced buffer system is the limited amount of buffering anions to the concentration 15 mM or less, preferentially 5 mM or less. In one version, the compositions contain borate or one or more borate/polyol complexes. Application of propylene glycol as polyol in such complexes is especially preferential. The limited amount of the bivalent metals different from zinc, and the amount of the present ionised salts, is important to maximise antimicrobial activity of the balanced buffer systems.

EFFECT: group of inventions provides prevention of the microbial infection, without the standard antimicrobial preservatives.

24 cl, 3 tbl, 13 ex