NEUROACTIVE 19-ALKOXY-17-SUBSTITUTED STEROIDS AND METHODS OF TREATMENT USING SAME Russian patent published in 2018 - IPC C07J1/00 C07J5/00 C07J7/00 C07J9/00 C07J13/00 C07J21/00 C07J41/00 A61K31/56 A61K31/566 A61K31/57 A61K31/575 A61K31/58 A61P23/00 

Abstract RU 2663665 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I-g) or a pharmaceutically acceptable salt thereof, where R1 chosen from (C1-C4 alkyl)-O, spirooxirane, cyano, =O, nitro, (C1-C4 alkyl)C(O) and HO(C1-C4 alkyl)C(O); R2 is H; R3 is H; Rb is methyl; R8 is H; - - - is an optional additional C-C bond providing a C=C bond between C16-C17, provided that, if present, R1 is not =O or spirooxirane. Invention also relates to individual compounds, a method for inducing anesthesia, to a method for treating disorders associated with the GABA function. .

EFFECT: technical result: obtaining novel compounds of formula (I-g), which can be useful in the treatment of disorders associated with the GABA function.

11 cl, 5 tbl

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RU 2 663 665 C2

Authors

Kouvi Duglas

Robichod Albert Dzhin

Dates

2018-08-08Published

2013-12-18Filed