FIELD: chemistry.
SUBSTANCE: invention refers to the field of carboxylic acid N-displaced amids synthesis that may be used in chemical industry, notably to the new way of amine acidylation. The method consists in interaction between the amine and acyl chloride in the inert solvent that is not mixed with water; the reaction is performed within the temperature range from 15 to 25°C by subsequent introduction of amine, lithium hydride, acyl chloride and water into the inert solvent, and extraction of the target product is performed by boiling-down of the spirit separated from the water layer.
EFFECT: increase of purity and yield of the end product and simplification of the extraction stage due to the high purity of the obtained amids.
3 cl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PREPARING CRYSTALLINE 7-[2-(2- AMINOTHIAZOLE-4-YL) -2(Z)-METHOXYIMINOACETAMIDO] -3-[(1- -METHYL -1-PYRROLIDINO) METHYL] -CEPH-3- EM-4-CARBOXYLATE DIHYDROCHLORIDE MONO- OR DIHYDRATE FREE FROM ANTIISOMER AND Δ-ISOMER | 1992 |
|
RU2039059C1 |
| METHOD OF SYNTHESIS OF CRYSTALLINE 7-[2-(2- AMINOTHIAZOLE-4-YL) -2-(Z)-METHOXYIMINOACETAMIDO]-3- [(-1-METHYL-1- PYRROLIDINIO) -METHYL]- CEPH-3-EM -4-CARBOXYLATE MONO- OR DIHYDRATE DIHYDROCHLORIDE ESSENTIALLY FREE FROM ANTIISOMER AND Δ-ISOMER | 1992 |
|
RU2042681C1 |
| IMPROVED METHODS OF MAYTANSINOL ACIDYLATION | 2013 |
|
RU2648992C2 |
| METHOD OF OBTAINING N-(ISO)NICOTINOYL- γ -AMINOBUTYRIC ACID AND ITS SODIUM OR POTASSIUM SALT | 2007 |
|
RU2337097C1 |
| IMPROVED MAITANZINOL ACYLATION METHODS | 2013 |
|
RU2765072C2 |
| NEW METHOD FOR PREPARING 5-(4-FLUOROPHENYL)-1-[2-(2R,4R)-4-HYDROXY-6-OXOTETRAHYDROPYRAN-2-YL)ETHYL]-2-ISOPROPYL-4-PHENYL-1H-PYRROL-3-CARBOXYLI9C ACID PHENYLAMIDE | 2001 |
|
RU2244714C1 |
| METHOD OF PRODUCING AROMATIC AMIDES OF 1-ADAMANTANE CARBOXYLIC ACID | 2019 |
|
RU2698193C1 |
| METHOD OF SYNTHESIS OF SUBSTITUTED N-ALLYLDICHLOROACETANILIDES | 1986 |
|
SU1438176A1 |
| METHOD OF PRODUCING BENZANILIDE | 2019 |
|
RU2712053C1 |
| CYCLOHEXANE IMIDAZOLYL SUBSTITUTED DERIVATIVES OR SALTS THEREOF | 1993 |
|
RU2110514C1 |
