FIELD: medicine.
SUBSTANCE: invention concerns medical products and covers applications of O- and S-glycosides 5-hydroxy-1,4-naphthoquinone (judlone) derivatives of formula 
1 as an agent that stimulates human leukaemia cell apoptosis. Disclosed compounds selectively stimulate human leukemia cell apoptosis as comparrf with a prototype juglone without affecting normal cells of human immune system (neutrophils).
EFFECT: invention allows extending range of products selectively stimulating leukaemia cell apoptosis.
4 cl, 13 dwg, 5 tbl, 14 ex
| Title | Year | Author | Number |
|---|---|---|---|
| AGENT STIMULATING APOPTOSIS OF HUMAN LEUKAEMIA CELLS | 2007 |
|
RU2360692C1 |
| ACETILIZED GLYCOSIDES OF 2,5- AND 2,8-DIHYDROXY-1,4-NAPHTHOQUINONES POSSESSING ANTIFUNGUS ACTIVITY | 0 |
|
SU1088346A1 |
| LABDANE-TYPE 6-HYDROXYNAPHTHOQUINONES, HAVING CYTOTOXIC ACTIVITY ON HUMAN TUMOUR CELLS | 2012 |
|
RU2479582C1 |
| METHOD FOR CELL PROTECTION AGAINST APOPTOSIS | 2013 |
|
RU2541774C2 |
| USE OF ACYLFULVEN ANALOGS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1994 |
|
RU2145849C1 |
| THERAPEUTIC QUINONES | 2005 |
|
RU2411229C2 |
| GLYCOSIDE DERIVATIVES OF 1,2-DITHIOL-3-THIONE OR 1,2-DITHIOL-3-ONE AND PHARMACEUTICAL PRODUCTS BASED ON THEM | 2013 |
|
RU2534525C9 |
| SMALL MOLECULE INHIBITORS OF THE PHOSPHORYLATED BCL-2-ASSOCIATED DEATH PROMOTER (BAD) | 2018 |
|
RU2799873C2 |
| METHOD FOR ASSESSING EFFECTIVENESS OF LYMPHOCYTE PROTECTION AGAINST APOPTOSIS | 2014 |
|
RU2568886C1 |
| AGONISTS OF PROTEIN TYROSINE PHOSPHATASE-1 CONTAINING HOMOLOGY-2 SRC DOMAIN, AND METHODS OF TREATING USING SAID AGONISTS | 2012 |
|
RU2584986C2 |
