FIELD: medicine.
SUBSTANCE: all the stages of host cell culture cultivation are implemented in multilayered HYPERFlask culture vessels. Also, the present invention provides an recombinant adenovirus preparation produced by the method according to the present invention.
EFFECT: method provides intensifying production of the recombinant adenovirus drug preparation, considerably reducing time and space resources required for manufacturing and storage, as well as considerably lowering the ratio of physical and infectious viral particles that leads to higher quality of the drug preparation.
12 cl, 2 tbl, 4 ex
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