FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to a technology of medical immunobiological preparations, and concerns a method for concentrating a native O-antigen Vibrio cholerae. Substance of the invention involves concentrating the native O-antigen Vibrio cholerae with the use of a membrane with nominal molecular weight cut-off 500 kDa in cross-flow filtration at pressure 0.24-0.26 MPa, average specific filtration rate (79±2) dm3/m2/h.
EFFECT: ensured higher processing rate and decreased O-antigen loss by 40% with maintained quality parameters of the preparation.
3 ex, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR CONCENTRATION OF NATIVE CHOLEROGEN-ANATOXIN AND O-ANTIGEN OF 569 V SEROVAR INABA STRAIN CLASSIC BIOVAR VIBRIO CHOLERAE 01 | 2011 |
|
RU2451522C1 |
| METHOD FOR PREPARING CHOLERAGEN ANATOXIN | 2013 |
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| METHOD OF PRODUCING CHOLERA TOXIN FOR CONTROL OF PRODUCTION OF CHOLERA CHEMICAL VACCINE | 2022 |
|
RU2799574C1 |
| AVIRULENT STRAIN OF Vibrio cholerae KM 263 BACTERIA OF SEROVAR INABA OF BIOVAR ELTOR - PRODUCER OF PROTECTIVE O1 ANTIGEN | 2010 |
|
RU2425867C1 |
| AVIRULENT STRAIN OF Vibrio cholerae KM 262 BACTERIA OF SEROVAR OGAWA OF BIOVAR ELTOR - PRODUCER OF PROTECTIVE O1 ANTIGEN | 2010 |
|
RU2425868C1 |
| CULTIVATED HYBRID CELL STRAIN OF Mus musculus L ANIMALS - PRODUCER OF MONOCLONAL ANTIBODIES SPECIFIC TO O-ANTIGENE OF CHOLERA VIBRIO SEROGROUP O1 | 2010 |
|
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|
RU2663102C2 |
| METHOD OF PREPARING PURIFIED CHOLERAIC 0-ANTIGEN | 1999 |
|
RU2143280C1 |
| METHOD OF VACCINE PRODUCING FOR CHOLERA PROPHYLAXIS | 1988 |
|
RU2080121C1 |
| COMPLEX GENE- AND IMMUNODIAGNOSTIC TEST-SYSTEM FOR IDENTIFICATION OF CHOLERA VIBRIONS OF O1 AND O139 SEROGROUPS AND ESTIMATION OF THEIR VIRULENCE | 2009 |
|
RU2404257C1 |
