FIELD: medicine.
SUBSTANCE: polypeptide (versions) immunogenic with respect to meningococcal infections contains: an amino acid sequence at least 90 % identical to a sequence presented in the description (SEQ ID NO: 32), or said amino acid sequence, or a fragment of 80 sequenced amino acids of said sequence. What is described is an antibody which contacts with the polypeptide under the invention and which may be used as a drug. What is described is nucleic acid of the preset structure which codes the polypeptide or its versions and which may be used for treating or preventing a disease and/or an infection caused by Neisseria meningitides. The invention provides additional polypeptides applicable in advanced vaccines for preventing and/or treating meningococcal meningitis. The peptides can also find application in diagnosing of the disease and as targets of antibiotics.
EFFECT: higher clinical effectiveness for meningococcal meningitis.
19 cl, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| MENINGOCOCCAL fHBP POLYPEPTIDES | 2009 |
|
RU2475496C2 |
| MENINGOCOCCAL fHBP POLYPEPTIDES | 2012 |
|
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| LIQUID VACCINES FOR MULTIPLE MENINGOCOCCAL SEROGROUPS | 2004 |
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| LIQUID VACCINE FOR MULTIPLE SEROGROUPS OF MENINGOCOCCUS | 2009 |
|
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|
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|
RU2557315C2 |
| NEISSERIA MENINGITIDIS COMPOSITIONS AND METHODS OF USE THEREOF | 2013 |
|
RU2665841C2 |
| IMPROVEMENTS DEALING WITH MENINGOCOCCUS OUTER MEMBRANE VESICLES | 2005 |
|
RU2420312C2 |
| COMBINATIONS OF MENINGOCOCCAL FACTOR-H-BINDING PROTEIN AND PNEUMOCOCCAL SACCHARIDE CONJUGATES | 2010 |
|
RU2555757C2 |
| MULTIPLE VERSIONS OF MENINGOCOCCAL PROTEIN NMB 1870 | 2003 |
|
RU2336091C2 |
