FIELD: medicine.
SUBSTANCE: nitrogen oxide deficiency is simulated by the daily 7-day intraperitoneal introduction of N-nitro-L-arginine methyl ester 25 mg/kg into experimental Wistar male rats. The nitrogen oxide deficiency is corrected by the simultaneous 7-day intragastric introduction of a combination of tadalafil 0.09 mg/kg and L-norvaline 10 mg/kg once a day.
EFFECT: effective management of the nitrogen oxide deficiency stimulated as described above by the therapeutic combination of the preparations first identified to this effect.
1 ex, 2 tbl
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