FIELD: chemistry.
SUBSTANCE: invention relates to an improved method of producing 4-(1-adamantyl)-1,2-diaminobenzene, which exhibits various types of biological activity. The method involves reaction of 1-bromoadamantane and o-phenylenediamine at temperature 180°C for 8 hours in molar ratio -bromoadamantane: o-phenylenediamine equal to 1:2-3.
EFFECT: method enables to obtain 4-(1-adamantyl)-1,2-diaminobenzene in a single step from readily available reactants without using highly toxic solvent with high output (55-76%).
1 dwg, 2 ex
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Authors
Dates
2012-06-27—Published
2011-02-14—Filed