FIELD: chemistry.
SUBSTANCE: invention relates to chemistry of adamantane derivatives and specifically to a method of producing 2-(adamantyl-1)-4-bromophenol, which is an intermediate product in the synthesis of adapalene - 6-[3-(adamantyl-1)-4-methoxyphenyl]-2- naphthoic acid, which is widely used in dermatology as an effective anti-acne agent. The method of producing 2-(adamantyl-1)-4-bromophenol involves reacting 4-bromophenol with 1-adamantanol and 1-bromoadamantane in molar ratio of 2:1:0.1, respectively, in the presence of 0.01 ml water or without water at temperature of 110-130°C for 2 hours.
EFFECT: simple, ecologically clean method of producing 2-(adamantyl-1)-4-bromophenol without using a catalyst and a solvent.
6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING ADAMANTYL-CONTAINING PHENOL HALIDE DERIVATIVES | 2011 |
|
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| METHOD OF PRODUCING 1-ADAMANTYLALKYL ESTERS | 2012 |
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| METHOD OF PRODUCING (1-ADAMANTYL)FURANES | 2017 |
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|
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| METHOD OF PRODUCING N-ADAMANTYLATED AMIDES | 2013 |
|
RU2549901C1 |
| METHOD OF PRODUCING ADAMANTYL-CONTAINING PHENOL DERIVATIVES | 2011 |
|
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| N-(1-ADAMANTYL)ACETAMIDE SYNTHESIS METHOD | 2008 |
|
RU2401828C2 |
| METHOD OF PRODUCING (1-ADAMANTYL)ACETONE (2-OXOPROPYLADAMANTANE) | 2012 |
|
RU2504535C2 |
| METHOD OF PRODUCING ADAMANTYL ESTERS OF UNSATURATED ACIDS | 2010 |
|
RU2448950C1 |
| METHOD FOR PRODUCING 4-(1-ADAMANTYL)ANILINE | 2014 |
|
RU2570909C1 |
