METHOD FOR PREDICTION OF CHRONIC DUST BRONCHITIS IN COAL MINE WORKERS Russian patent published in 2012 - IPC G01N33/53 G01N33/48 

FIELD: medicine.

SUBSTANCE: method for prediction of a risk of chronic dust bronchitis in coal mine workers consists in blood examination for genetic markers. It involves the genetic markers of systems: haptoglobin (HP), group-specific component (GC), fluorescent esterase (EsD), erythrocyte acid phosphatase (AcP). A prognostic coefficient (PC) score is calculated. If the marker 1-1 is found in the HP system, the PC is specified to be equal to (+1.5); the marker 1-2 makes the PC to be equal to (+0.1), while the marker 2-2 shows the PC (-1.1). If the marker 1-1 is found in the GC system, the PC is specified to be equal to (-1.9); the marker 1-2 makes the PC to be equal to (+1.7), while the marker 2-2 shows the PC (+5.5). If the marker 1-1 is found in the EsD system, the PC is specified to be equal to (-1.2); the marker 1-2 makes the PC to be equal to (+2.3), while the marker 2-2 shows the PC (+3). If the AcP system comprises the marker (aa), the PC is equal to (-5); the marker (ab) shows the PC equal to (0); the marker (bb) provides the PC to be equal to (+3.6); the marker (ac) - the PC equal to (+2.2), the marker (bc) - the PC equal to (-2.4), the marker (ee) - the PC equal to (-3.5). The PC for all the markers are summed up; total PC being (+5) and more enables predicting the propensity for chronic dust bronchitis, while total PC equal (-5) and less shows resistance to chronic dust bronchitis.

EFFECT: use of the declared method enables higher accuracy of prediction of chronic dust bronchitis in coal mine workers.

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