METHOD FOR PREDICTION OF RISK OF DEVELOPING ANTHRACOSILICOSIS IN COAL MINERS Russian patent published in 2013 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: blood is examined for the genetic markers. It involves the genetic markers of systems: haptoglobin (HP), group-specific component (GC), fluorescent esterase (EsD), erythrocyte acid phosphatase (AcP). A prognostic coefficient (PC) score is calculated for each marker. If the marker 1-1 is found in the HP system, the PC is specified to be equal to PC=(+2.4); the marker 1-2 makes the PC to be equal to (0), while the marker 2-2 shows the PC (-1.6). If the marker 1-1 is found in the GC system, the PC is specified to be equal to (-1.4); the marker 1-2 makes the PC to be equal to (+1.7), while the marker 2-2 shows the PC (+3.7). If the marker 1-1 is found in the EsD system, the PC is specified to be equal to (-1.4); the marker 1-2 makes the PC to be equal to (+2.6), while the marker 2-2 shows the PC (+3). If the AcP system comprises the marker (aa), the PC is equal to (-2.2); the marker (ab) shows the PC equal to (0); the marker (bb) provides the PC to be equal to (+3.6); the marker (ac) - the PC equal to (+2.2), the marker (bc) - the PC equal to (-4.5), the marker (cc) - the PC equal to (-5.2). The PCs of all the markers are summed up taking into account their sign. If total PS is found to be equal to (+5) and more, the propensity for developing anthracosilicosis is predicted. Total PC (-5) and less ensures predicting resistance to developing AS.

EFFECT: use of the declared method enables higher accuracy and information value of the prediction of developing anthracosilicosis.

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