FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to using compounds of (R,S)-2-arylpropionic acids of the formula (Ia) 
, and their (R)- and (S)-isomers as inhibitors of neutrophile (PMN leukocytes) chemotaxis induced by IL-8. These compounds elicit unexpected ability to inhibit effectively IL-8-induced chemotaxis and degranulation of neutrophiles being without significant effect on activity of cyclooxygenases. These compounds can be used in treatment of such diseases as psoriasis, ulcerated colitis, melanoma, chronic obstructive pulmonary disease, bulla pemphigus, rheumatic arthritis, idiopathic fibrosis, glomerulonephritis, and for prophylaxis and treatment of damages induced by ischemia and reperfusion.
EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions.
9 cl, 3 tbl, 43 ex
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