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IPC

G09B23/28(2006-01-01)

A61B17/132(2006-01-01)

A61M1/10(2006-01-01)

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Application

2011116372/14, 2011-04-25

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Start date

2011-04-25

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Actual filing date

2011-04-25

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Published

2012-08-27

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Inventor

Pokrovskij Mikhail VladimirovichGureev Vladimir VladimirovichPoljanskaja Oksana SergeevnaKorokina Lilija ViktorovnaPokrovskaja Tat'Jana Grigor'EvnaGureeva Elena Gennad'EvnaKochkarov Vladimir IskhakovichBondarenko Evgenija Valer'EvnaDanilenko Ljudmila MikhajlovnaZhernakov Evgenij VladislavovichGolovchenko Il'Ja OlegovichKhadieva Taisija AbduladirovnaPakhomov Sergej PetrovichDenisjuk Tat'Jana AlekseevnaKotel'Nikova Lilija ViktorovnaAlekhin Sergej AleksandrovichAlekhina Valerija Valer'EvnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichBelous Aleksandr SergeevichTsybul'Skij Igor' Valer'Evich

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet" Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija Rossijskoj Federatsii

METHOD FOR PLACENTAL MICROCIRCULATION DISORDER CORRECTION IN ADMA-LIKE GESTOSIS MODEL Russian patent published in 2012 - IPC G09B23/28 A61B17/132 A61M1/10 

Abstract RU 2460148 C1

FIELD: medicine.

SUBSTANCE: method involves reproducing a gestosis model in Wistar rats by the daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg for 14th to 20th day of pregnancy. The modelled pathology is corrected by the daily distant pre-conditioning from the 10th to 20th week of pregnancy. That is ensured by 10-minute cross-clamping of the femoral artery once a day by applying a cuff on an upper one-third of thigh followed by reperfusion.

EFFECT: improved placental microcirculation ensured by anti-ischemic protective action on the body and provided NO bioavailability with endothelial dysfunction correction.

1 ex

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RU 2 460 148 C1

Authors

Pokrovskij Mikhail Vladimirovich

Gureev Vladimir Vladimirovich

Poljanskaja Oksana Sergeevna

Korokina Lilija Viktorovna

Pokrovskaja Tat'Jana Grigor'Evna

Gureeva Elena Gennad'Evna

Kochkarov Vladimir Iskhakovich

Bondarenko Evgenija Valer'Evna

Danilenko Ljudmila Mikhajlovna

Zhernakov Evgenij Vladislavovich

Golovchenko Il'Ja Olegovich

Khadieva Taisija Abduladirovna

Pakhomov Sergej Petrovich

Denisjuk Tat'Jana Alekseevna

Kotel'Nikova Lilija Viktorovna

Alekhin Sergej Aleksandrovich

Alekhina Valerija Valer'Evna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Belous Aleksandr Sergeevich

Tsybul'Skij Igor' Valer'Evich

Dates

2012-08-27—Published

2011-04-25—Filed

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