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IPC

G09B23/28(2006-01-01)

A61B17/132(2006-01-01)

A61M1/10(2006-01-01)

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Application

2012108543/14, 2012-03-07

(24)

Start date

2012-03-07

(22)

Actual filing date

2012-03-07

(45)

Published

2014-02-20

(72)

Inventor

Pokrovskij Mikhail VladimirovichPokrovskaja Tat'Jana Grigor'EvnaKochkarov Vladimir IskhakovichKorokin Mikhail ViktorovichGudyrev Oleg SergeevichArustamova Anna AleksandrovnaGureev Vladimir VladimirovichPoljanskaja Oksana SergeevnaZhernakova Nina IvanovnaTsybul'Skij Igor' Valer'EvichAlekhin Sergej AleksandrovichKolesnik Inga Mikhajlovna

(73)

Holder

Federal'Noe Gosudarstvennoe Avtonomnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Natsional'Nyj Issledovatel'Skij Universitet"

METHOD FOR ENDOTHELIAL DYSFUNCTION CORRECTION IN ADMA-LIKE GESTOSIS MODEL IN EXPERIMENT Russian patent published in 2014 - IPC G09B23/28 A61B17/132 A61M1/10

Abstract RU 2507594 C2

FIELD: medicine.

SUBSTANCE: method involves simulating gestosis in Wistar rats by the daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg for 7 days from the 14^th day of pregnancy. That is followed by a single simulation of a 10-minute remote ischemic episode on the hind limb on the 21st day of pregnancy by femoral artery clamping and reperfusion. Vascular tests follow 90 minutes later, and an endothelial dysfunction coefficient is calculated.

EFFECT: method enables studying the NO-independent protective mechanisms accompanying the endothelial dysfunction correction in the specific experimental environment.

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RU 2 507 594 C2

Authors

Pokrovskij Mikhail Vladimirovich

Pokrovskaja Tat'Jana Grigor'Evna

Kochkarov Vladimir Iskhakovich

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Arustamova Anna Aleksandrovna

Gureev Vladimir Vladimirovich

Poljanskaja Oksana Sergeevna

Zhernakova Nina Ivanovna

Tsybul'Skij Igor' Valer'Evich

Alekhin Sergej Aleksandrovich

Kolesnik Inga Mikhajlovna

Dates

2014-02-20—Published

2012-03-07—Filed