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2 696 196

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IPC

G09B23/28(2006-01-01)

A61K31/495(2006-01-01)

A61P9/08(2006-01-01)

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Application

2018132815, 2018-09-14

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Start date

2018-09-14

(22)

Actual filing date

2018-09-14

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Published

2019-07-31

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Inventor

Antsiferova Oksana EvgenevnaYurakova Alesya ViktorovnaLokteva Tatyana IvanovnaGureev Vladimir VladimirovichPokrovskij Mikhail VladimirovichPokrovskaya Tatyana GrigorevnaPeresypkina Anna AleksandrovnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichPobeda Anna SergeevnaYakushev Vladimir IvanovichKorokina Liliya ViktorovnaLazareva Galina AnatolevnaGureeva Elena GennadievnaZhilinkova Lyudmila AnatolevnaZotolokina Mariya AlekseevnaShchurovskaya Kristina Vladimirovna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD OF CORRECTION OF PLACENTAL MICROCIRCULATION DISORDERS WITH ADMA-LIKE MODEL OF PREECLAMPSIA Russian patent published in 2019 - IPC G09B23/28 A61K31/495 A61P9/08

Abstract RU 2696196 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to experimental pharmacology, and can be used for correction of placental microcirculation disorders with ADMA-like model preeclampsia. Model is reproduced preeclampsia in Wistar rats for 7 days every day from 14 to 20 of pregnancy, intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg. Against the background of simulated pathology, intragasting is administered through a probe of trimetazidine daily single dose of 6 mg/kg from 14 to 20 days of pregnancy.

EFFECT: method provides pronounced correction of placental microcirculation disorders with ADMA-like model preeclampsia using trimetazidine in experiment as a result of pronounced anti-ischemic and antioxidant action of trimetazidine.

1 cl, 1 tbl, 1 ex

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RU 2 696 196 C1

Authors

Antsiferova Oksana Evgenevna

Yurakova Alesya Viktorovna

Lokteva Tatyana Ivanovna

Gureev Vladimir Vladimirovich

Pokrovskij Mikhail Vladimirovich

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Pobeda Anna Sergeevna

Yakushev Vladimir Ivanovich

Korokina Liliya Viktorovna

Lazareva Galina Anatolevna

Gureeva Elena Gennadievna

Zhilinkova Lyudmila Anatolevna

Zotolokina Mariya Alekseevna

Shchurovskaya Kristina Vladimirovna

Dates

2019-07-31—Published

2018-09-14—Filed