METHOD FOR CORRECTION OF PLACENTAL MICROCIRCULATION DISORDER BY ARGINASE II INHIBITOR Russian patent published in 2018 - IPC G09B23/28 A61K31/195 A61P9/08 A61P15/06 

FIELD: pharmacology.

SUBSTANCE: method involves the reproduction of an ADMA-like model of gestosis in laboratory pregnant Wistar rats by daily intraperitoneal administration of the NO-synthase inhibitor L-NAME from day 14 to day 20 of pregnancy at a dose of 25 mg/kg/day. Correction of microcirculation disturbances in the placenta is carried out by intragastric administration of the selective inhibitor of arginase II-KUD975. Administration is performed 30 minutes before the administration of L-NAME, a selective inhibitor of arginase II at a dose of 1 mg/kg of animal body weight.

EFFECT: effective correction of placental microcirculation disorders with the exclusion of side effects characteristic of low- and nonselective arginase inhibitors.

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